Typical Applications s In situ measurement of dissolved CO2 s Monitor fermentation s Analyze cell culture processes s Observe metabolism changes systems & accessories Fully Autoclavable, Fits Into Most Bioreactors This rugged sensor is a disposable, autoclavable capsule that inserts into a stainless steel probe. Installation of the sensor capsule is simple. Multiple probe styles are available now with more being developed. See your process in a new light YSI’s patented opto-chemical sensor technology enables scientists, technicians, and Standard Features production managers to opti- • Accurate in situ measurement mize critical fermentation and cell culture processes through • Single point calibration continuous in situ monitoring of dissolved carbon dioxide. cell metabolism and other Engineered to fit with a vari- changes within the bioreactor. With single point calibration 8500 delivers real-time data and a lower system cost than to help you gain insight into most blood gas analyzers, the modular YSI 8500 is the most reliable, cost-effective way to measure CO2. • Easy-to-replace disposable sensor capsules • Real-time response • Does not consume CO2 • User-defined data logging intervals, as frequently as every 15 seconds • Rugged, reusable stainless steel probes in multiple styles

Patented opto-chemical technology gives you the competitive edge Why Measure Dissolved CO2? The measurement of dissolved CO2 provides data that is Optical Fiber Perforated Stainless Steel Layer Outer Inert Polymer Layer (Opaque) Inner Polymer Layer (Transparent) Stainless Steel Probe Body consistent with the true cellular environment. Dissolved CO2 can provide valuable cellular metabolic information which can be used to improve cell viability, maximize the production of the product being generated by the cell, and improve the quality of the product of YSI has successfully commercialized innovative...

YSI 8500 BioVision systems & accessories Flexible Calibration and Monitoring Parameters Although a single point calibration at the start of each run is required for optimum accuracy, this vital step is quick and easy. It can be completed in process by using a certified reference gas or blood gas analyzer. The user sets the data logging points, choosing to measure as often as every 15 seconds, or collecting data at longer intervals to reflect the length of a particular run. Data can be read directly from the YSI 8500 monitor display, uploaded to a computer or incorporated into your control process....

Engineered to fit a variety of bioreactors, rugged, reusable stainless steel probes are autoclavable and offer easy-to-change sensor capsules. YSI 8500 Evaluated at Northwestern University “ . . . Setup and operation of the 8500 and the CO2 probe were straightforward, following the steps in the user manual. Initial trial runs in a cell-free bioreactor were carried out by gassing a phosphatebuffered saline (PBS) solution with 195mm Hg pCO2, which was verified on a blood gas analyzer (BGA). Once the 8500 response had stabilized, the probe was calibrated using the dissolved pCO2value measured using...