ACQUITY UPC2
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THE SCIENCE OF WHAT'S POSSIBLE.™

As we embarked upon the process of combining our ultra performance technology with this new system, we discovered performance that expands the boundaries of LC and GC separations – providing not only the ultimate solution for routine analysis but dramatically streamlining workflow. WE WERE SEEING LEVELS OF SENSITIVITY

NOT SEEN BEFORE. Introducing ™ ACQUITY UltraPerformance Convergence Chromatography.

The paradigm has shifted. ™ UPC2™ stands for UltraPerformance Convergence Chromatography, a new category of separations science, one that marries the unrealized potential of SFC with Waters® proven UPLC ® technology and expertise in the 2 management of fluids, temperature, and pressure. With ACQUITY UPC, ™ Waters has pushed the boundaries of system design so scientists can push the boundaries of science. UPC2 can be coupled with a range of Waters MS solutions previously considered incompatible with normal phase chromatography or SFC systems, due to interface limitations and software...

THE SEPARATION PERFORMANCE EXCEEDED OUR EX PECTATIONS.

How we got here. Where you can take it. 2 Compressed carbon dioxide (CO2), the primary mobile phase for UPC, offers numerous major advantages over liquid mobile phases or carrier gases that are used with LC and GC. For one, CO2 alone, or combined with a co-solvent, is a low viscosity mobile phase that achieves higher diffusion rates and enhanced mass transfer than liquids used in HPLC. For another, when compared to GC, CO2 alone is a mobile phase that allows separations to occur at a much lower temperature. 0.32 0.30 ACQUITY U P C2 achiral separation of an 18 compound mixture with an...

Scientists can routinely separate compounds that are less amenable to analysis by LC and GC including molecules having a wide range of polarities. Along with industry leading sub two-micron particle technology column chemistries, the ACQUITY UPC2 System gives scientists the ability to precisely vary mobile phase strength, pressure, and temperature. With this ability to fine-tune the resolving power and selectivity of the system, scientists can exercise better control over the retention of analytes for separating, detecting, and quantifying structural analogs, isomers, and enantiomeric and...

Why ACQUITY UPC2 ? A Complete System Solution, Backed by Waters. Built around our proven UPLC platform, the ACQUITY UPC2 System applies Waters’ trademarked ruggedness, reliability, and ease-of-use to your most challenging separations. It’s a complete solution that maximizes the benefits of Waters chemistries and industryleading informatics software, and services, empowering your lab with: ■■ Unmatched performance with unparalleled separations and peak shape, which allows you to see and do so much more than traditional SFC applications. At the same time, you can move into chiral and achiral...

Reduction in solvent usage lead to >100 fold decrease in cost per sample. Total analysis time: 18 s ACQUITY UPC 2 chiral analysis of warfarin. ACQUITY UPC achiral analysis of tolbutamide and tolazamide. CHIRALPAK IB-3 (2.1 x 50 mm, 3 µm) Isocratic: 15% Methanol 3 mL/min 120 bar Chiral comparison of ACQUITY UPC 2 vs. normal phase HPLC Achiral comparison of ACQUITY UPC 2 vs. normal phase HPLC Normal phase HPLC achiral analysis of tolbutamide and tolazamide. Normal phase HPLC chiral analysis of warfarin. A NEW CATEGORY OF SEPARATIONS SCIENCE.

Increased confidence in chiral analysis. MS/MS Data of Methamphetamine (25 pg on column) 9000.0 Chiral compounds continue to play a vital role in the pharmaceutical and chemical industries. Separation of enantiomers that are the same molecular weight but are mirror images represents a difficult chromatographic challenge. SFC has demonstrated suitability and advantages over any other technique to separate enantiomers. With UPC 2 scientists can , confidently push the boundaries of method development and analysis of chiral mixtures. So no matter what your scientific challenge, UPC2 has a...

Now you can analyze a diverse range of compounds with the ACQUITY UPC 2 System. Hydrophilic ESSENTIAL TOOL THAT HAD ANALYTICAL TOOLBOX. DISCOV E R W HAT YOU’RE MISSING. Every laboratory has samples that are simply too complex to pursue. Not anymore. With an ACQUITY UPC2 System from Waters, you’re not only expanding the potential of your team, you’re unlocking the possibilities of science. Contact us today. Or, to learn more, visit waters.com/UPC2.

SALES OFFICES: Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 508 478 2000 F: 508 872 1990 www.waters.com UPLC, UltraPerformance LC, Waters, and Waters Quality Parts are registered trademarks of Waters 2 Corporation. ACQUITY UltraPerformance Convergence Chromatography, UPC, UltraPerformance 2 Convergence Chromatography, ACQUITY UPC, Empower, MassLynx, and The Science of What’s Possible are trademarks of Waters Corporation. All other trademarks are the property of their respective owners. ©2012 Waters Corporation. Printed in the U.S.A. November 2012 720004225EN LL-IGS