Comprehensive compounding and extrusion solutions for materials science Streamlining continuous workflows

Twin-screw extrusion Mixing. Compounding. Processing. Why use twin-screw extrusion and compounding? Twin-screw extruders are well-established for the mixing, compounding, and processing of polymeric materials. They are used in a wide variety of polymer, pharmaceutical, and food applications to efficiently develop and produce high-quality products using a continuous process. The modularity of twin-screw extrusion equipment provides great flexibility in the design of a process to accomplish your goals. Choose from a wide range of customizable options for twin-screw extruders designed to fit the...

In-depth expertise Good science builds knowledge If your company develops and manufactures new products in a competitive environment, it’s vital that your equipment manufacturer has extensive expertise to meet the process challenges your industry faces. We are scientists and engineers with over 50 years of experience in producing solutions in the field of materials sciences. Delivering accurate and reproducible solutions are our top priorities to help you shorten time-to-market for your product. We have developed methods that make it easier for you to optimize your process research and development,...

Micro-compounding Feasibility testing with less waste Our line of micro-compounders with conical twin-screws is well-suited for research and development in the polymer, pharmaceutical, bioscience, and nanotechnology industries. All models use as little as five grams or seven milliliters of material for compounding. This is especially beneficial if you compound expensive or small-scale materials. By using the optional force feeder attachment, you can continuously extrude very small material volumes. These small-scale instruments are based on proven conical twin-screw technology with co- and counter-rotating...

Pharma mini HME Micro-Compounder Use for special requirements demanded by the pharmaceutical industry. With a completely modular and removable barrel and crevice-free design, this machine provides enhanced features for pharmaceutical API/excipient formulations and regulated environments. The HME process is ideal for feasibility testing of poorly soluble ingredients that require improved bioavailability. • GMP design and validation protocols for pharmaceutical manufacturers • Fast and easy feasibility testing of API/excipient formulations for HME • Quick disassembly to minimize cross- contamination...

Laboratory-scale extruders Optimize for scale-up with less risk Simulate production and optimize your process with Thermo Scientific laboratory-scale extruders. Feed different additives (solid, liquid, or gas) along the various barrel ports, while measuring material properties of the melt using in-line sensors. Our twin-screw extruders can be quickly and easily configured for a wide variety of applications and test conditions Benchtop twin-screw compounders offer unique flexibility Mimic a complete compounding line, including feed equipment and downstream equipment, for developing industrial...

Pharma 11 Twin-Screw Extruder Use this very small, scalable extruder to switch from hot melt extrusion (HME) to twin-screw granulation (TSG) for a wide range of drug development applications. With a minimum throughput of just 20 g/h, it is ideal for research and development applications when assessing expensive API/ excipient formulations. Achieve GMP compliance with the Pharma 11 Twin-Screw Extruder, which is suitable for the production of validation batches, clinical trial materials, and small-scale production for throughputs up to 2.5 kg/h. Full validation is available for FAT, SAT, IQ/OQ,...

Laboratory Scale Optimize your process in less time Develop your process knowing that you can transfer parameters to the next scale with fewer test runs. HAAKE PolyLab OS System Measure rheological properties of your material and control process parameters when you connect the PolyLab OS rheometer platform to any Rheomex extruder. The PolyLab OS System provides: • An on-line torque rheometer • Extrusion process control software • Connectivity between extrusion accessories and sensors Rheomex PTW 16 OS Twin-Screw Extruder Use this parallel twin-screw, small-scale compounder for running early-stage...

Rheomex PTW 24 OS Twin-Screw Extruder Use this 24 mm screw-diameter extruder for laboratory applications with higher throughput needs. The barrel layout and screw geometries are taken directly from the production process. The individually configurable barrel and screws enable users to adapt to changing requirements in compound development and process optimization. • Quick setup for high-throughput, continuous compounding applications • Easy to configure barrels/screws when changing from one material to another Rheomex PTW 100 OS Twin-Screw Extruder Use this counter-rotating, conical twin-screw...

Pilot-scale processing and production Flexible compounding with less effort Smaller, pilot-scale extruders are an excellent choice when working with modest quantities of expensive or difficult polymers and pharmaceutical ingredients. Thermo Scientific twin-screw extruders offer flexible compounding configurations that can move you from small batches in labscale production to pilot-scale production or low-volume manufacturing. The co-rotating, twin-screw extruders feature: • Segmented screws and modular barrels; split-barrel design with barrel-liners • Industrial standard Siemens PLC* for seamless...

Pharma 16 Twin-Screw Extruder Use this 2-in-1 extruder to switch from an HME and a TSG process when developing drug formulations or performing scale-up studies. The co-rotating screws provide easy track recording and handling. Ensure reliable and reproducible results with a PLC system that archives formulation data matched to specific process parameters. A clamshell barrel with removable liners allows easy cleaning of contact parts without disconnecting the barrel. Produce multiple samples from small amounts of API with minimal scale-up risks. • Switch from HME to TSG process with one instrument...