Coulochem III Electrochemical Detector Brochure
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Thermo Scientific Dionex Coulochem III Electrochemical Detector Electrochemical Detection

Ideal for a Wide Range of Applications The Thermo Scientific Dionex Coulochem III is the standard for electrochemical detection: no other HPLC detector has greater sensitivity, selectivity, and as wide a dynamic range. With picogram to femtogram limits of detection, the Coulochem™ III detector is ideal for a wide range of applications including: Neuroscience Measure neurotransmitters from the smallest regions and with shorter collection times. Pharmaceutical From drug discovery to quality control, the inherent sensitivity and selectivity of this detector enables measurement of ultra-low...

Electrochemical detection (ECD) is typically chosen for its extreme sensitivity; no electrochemical detector is more sensitive than the Coulochem III. The detector independently controls multiple channels: two for analyses, and an additional channel—unique to the Coulochem III—for mobile phase cleaning or sample pretreatment. Electrochemical detection is sensitive because it measures the very small currents produced when low levels of compounds undergo redox reactions. The sensitive Boron Doped Diamond electrode extends the range of compounds typically measured using glassy carbon...

Selectivity Often, the analytical chemist is faced with co-eluting analytes. The unique selectivity of the coulometric cell enables resolution of co-eluting peaks. In coulometric detection, compound A reacts completely at Electrode 1, thus eliminating it from detection at Electrode 2. Compound B passes Electrode 1 unchanged and is detected at Electrode 2. As a result, A and B are resolved electrochemically. This lets you operate in redox or screen mode, providing greater selectivity—often reducing sample preparation and eliminating interferences. The Coulochem III detector offers DC, Pulse/...

Flexibility The Coulochem III detector provides optimized solutions that give you flexibility in experimental design, instrument configuration, and cell options, now and for the future. Choice of cells The Coulochem III detector comes with a choice of cell designs and electrode materials. All have a solid-state, maintenance-free reference electrode known worldwide for its reliability. Coulometric, amperometric, or specialty cells–all used with the same detector. Organizer Module An optional organizer module houses multiple columns and cells, protecting them from the environment. It is...

Sensitivity, Selectivity, Reliability, and Flexibility All In One Detector Maximize Sensitivity: Neurotransmitters Faster analysis enables shorter collection times and improved temporal resolution in microdialysis experiments. Extensive research by our Applications Laboratory has determined that the ideal configuration for sensitivity and reliability is the Model 5041A cell with a 2 mm column. Enhance Selectivity with Redox Mode: Plasma Catecholamines High selectivity and sensitivity can be achieved through the dual working electrodes of the coulometric cells. In plasma catecholamine...

Synthesis: Drug Metabolites Synthesize authentic drug metabolites in hours instead of months, in quantities suitable for NMR, MS, or biological studies. Connect on-line with MS or go off-line to collect metabolites in microgram quantities. Electrochemistry with Mass Spectrometry: Assisted Ionization Use the coulometric cell to provide additional capabilities with your LC-MS system. Ionize problem compounds to enable or enhance MS detectability. Use this approach to identify parent compounds and reaction products or metabolites. I Amitriptyline II Nortriptyline III DiNortriptyline II...

The Value of Support and Service Customer care begins after delivery—when you purchase any Thermo Scientific instrument, module, or system, you get a partner, not just a piece of equipment. We provide access to a wide range of quality post-installation programs and assistance; including expert customer training, comprehensive service agreements, validation and qualification services, application support, and timely, professional service by skilled, locally based representatives. Our service representatives are distributed around the world, but close to you, ready to provide professional...