Corona CAD Charged Aerosol Detector Know what is really in your sample Passion. Power. Productivity.

Meaningful Answers from One HPLC Detector What is the best way to detect and quantify analytes with HPLC? There is no simple answer. UV detection is the most widely used, but fails to detect analytes without chromophores. Other, so-called “universal detectors” have fallen short of the promise of combining application versatility with reliability. For many, MS is not the answer. Now there is a solution – the Corona® Charged Aerosol Detector (CAD®). Based on a unique and innovative detection method, the Corona CAD detector offers performance that refractive index (RI), low wavelength UV, evaporative...

How Charged Aerosol Detection Works Charged Aerosol Detection What makes any detector useful is its ability to accurately measure a wide range of analytes with consistent response. However, most detectors exhibit limitations. Often, one analyte responds more strongly than another, or may not respond at all. The Corona CAD detector measures charge that is imparted to analyte particles, with the charge being in direct proportion to the amount of the analyte in the sample. Measuring this charge is accurate and consistent, regardless of the analyte. The result is that the Corona CAD detector can...

Consistent Response with Low Limits of Detection Consistent Response Detector Response for Nonvolatiles 10.7% RSD variation in CAD response among 1.0 µg samples by flow injection 250,000 200,000 150,000 100,000 50,000 Warfarin Gentisic acid Tartaric acid Salicylic acid The response obtained with the Corona CAD for nonvolatile analytes is less dependent on chemical structure than other detectors. As shown in the figure, charged aerosol detection response by flow injection analysis is very similar for equivalent amounts of a wide diversity of structures. Charged aerosol detection response does...

Enhanced Performance Gradient Compatibility The Corona CAD detector is fully compatible with gradient operation. Volatile mobile phases such as those used with MS are appropriate for use with the Corona CAD. The figure shows a five minute linear gradient from 10 mM ammonium acetate/2% IPA in H20 to 10 mM ammonium acetate in 75% ACN/25% MeOH. In the example, note the increased nebulization efficiency with increased organic solvent observed during a reversed phase gradient. Wide Dynamic Range 1.E+06 Height 1.E+05 Gallic acid Chlorogenic acid Protocatechuic acid 1.E+04 0.1 At the right are overlaid...

Superior Performance for your Applications Sodium Chloride 0.15% Chloride Spike 0.1% Chloride Spike No Spike Complementary and Orthogonal Data The Corona CAD’s unique method of detection produces data complementary to that of UV and MS. When three detectors are used to analyze the same sample, all respond based on distinctly different physicochemical properties, providing truly orthogonal data. MS only detected two of the three species. With the Corona CAD, three peaks with similar responses were observed – you not only see what you think is in your sample, but what is actually there. Comparison...

Quick start-up, easy operation Compatible and versatile Integrates easily with any HPLC system. Easy to read display Brilliant, high contrast readout provides all essential information. Simple to operate Set gain and gas flow, and you are up and running. Soft key operation Robust, intuitive keypad design. Gas flow control Touchpad control with LED status indicator. Programmable Store 25 methods. Recall and launch methods easily. Change gain on the fly. Select from 3 preset filters. Flexibility Run from the keypad or control the Corona CAD from your PC. Security Built-in security features help...

Discover Charged Aerosol Detection In the world of HPLC, one detection technology stands out. Charged aerosol detection has response independent of analyte structure, provides consistent responses across a range of nonvolatile analytes, has a wide dynamic range, broad applicability, and is as easy to use as UV. Enjoy Industry-Leading Support Dionex customer Support Centers are located in the Americas, Europe and Asia and provide accessible locations for advanced training and enhanced application development capabilities. Users can visit these laboratories to learn new skills in addressing challenging...