automated synthesis system
68Pages

automated synthesis system Batch Reactor Manual 5 -Atlas and Globe 3 Bar Pressure Systems Syrris Ltd Version: Author: Date: P/N: Disclosure This document is confidential and is the property of Syrris Ltd. No attempt should be made to copy this document in any way without prior consent. © 2013 Syrris Ltd all rights reserved

[Page left blank] Syrris Ltd: Atlas Pressure Systems - Manual Page 2 of 68 Chapter: Introduction

Syrris Ltd: Atlas Pressure Systems - Manual Chapter: Introduction

Syrris Ltd: Atlas Pressure Systems - Manual Page 4 of 68 Chapter: Introduction

1 Introduction Thank you for purchasing an Atlas or Globe 3 Bar Pressure System from Syrris. These instructions have been carefully prepared to guide the installer and end-user through the installation and use of the Atlas Potassium 3 Bar Pressure System and Globe 3 Bar Pressure System. Before attempting to use this product, please read this manual thoroughly and follow the instructions carefully. In doing so, you will ensure the safety of yourself and others around you and you can look forward to your purchase giving you a long and satisfactory service. Designed specifically for ease of...

2 Safety All Syrris reactors are designed and manufactured to ensure safe operation when used within their prescribed temperature and pressure limits, but the basic responsibility for safety using the equipment rests entirely with the user. This equipment should only be used by competent, suitably trained personnel after they have read and understood the operating instructions and considered any hazard involved. 2.1 Warning and Safety Information for Atlas Potassium 3 Bar Pressure Systems and Globe 3 Bar Pressure Systems 2.1.1 General Precautions The system must only be pressurised when...

2.1.3 Operational Safety Because of the high risk of injury or major damage which may occur with the failure of any part of a pressure system, it is essential that such systems are set up, used and maintained in a safe manner. Due to the brittle nature of glass, it is essential that safety screens are used and the system is installed in a suitable protective fumehood with a closed shatterproof door. Flying fragments from an exploding glass vessel can be fatal. The user must have a complete understanding of the reaction planned to be run and carry out a risk assesment before starting the...

The user must ensure that there are adequate safety systems to prevent reactor pressure exceeding maximum allowable working pressure as displayed on the reactor. Do not overfill the vessel and account for any thermal expansion during a reaction. The pressure relief valve is factory set to open at 2.75bar to assist in preventing over pressure. The safety valve closes after relieving the over pressure. Safety valves can be become clogged and therefore do not guarantee complete protection. The user must ensure there are adequate safety systems to prevent reactor temperature exceeding maximum...

• Maximum Allowable Working Pressure: +3 barg 2.1.5 ATEX This product does NOT comply with the ATEX directive and must NOT be used in explosive atmospheres. 2.1.6 Cleaning Cleaning should only be performed by personnel trained in such work, and who are aware of the possible dangers involved. Atlas (and all the associated hardware) has not been designed for sterilization or use with an autoclave. Atlas may contain hot components, allow the unit to cool before performing any cleaning operations. The On/Off switch must be in the OFF position and the unit disconnected from both mains and...

2.1.7 Maintenance Maintenance should only be attempted by qualified service personnel or under guidance by Syrris. Atlas may contain hot components, allow the unit to cool before performing any maintenance operations. The On/Off switch must be in the OFF position and the unit disconnected from the mains and any apparatus. Disconnect gas inputs and ensure any pressure in the system is safely vented before performing any maintenance operations. The safety manifold including pressure relief valve operation must be checked as part of a scheduled maintenance program. See Section 9.1.1 Atlas...

2.2 Returning Equipment Equipment which has been contaminated with, or exposed to, body fluids, toxic chemicals or any other substance hazardous to health must be decontaminated before it is returned to Syrris or its distributor. Complete the Syrris decontamination certificate (See section 12.2) and return with the equipment. 2.3 Environmental Conditions Usage For indoor use only Temperature range: 5°C to 40°C Humidity: Maximum relative humidity of 80% 2.4 Waste Electrical and Electronic Equipment (WEEE) statement Syrris is compliant with the EU directive 2002/96/EC on waste electrical and...

This section is designed to give an overview of the hardware used in the Syrris 3 Bar pressure systems. The hardware overview will include the configuration of parts and explanation on individual components specifically required for the Atlas Potassium 3 Bar Pressure System and Globe 3 Bar Pressure System. The following Reactor Systems are covered in this manual: • Atlas Potassium 3 Bar Pressure System o Automated glass jacketed reactor system with a volume range of 100ml to 3L, designed for pressure applications up to 3 bar. • Globe 3 Bar Pressure System o Manual glass jacketed reactor...

Atlas Volumetric Dosing: Add the Atlas Syringe Pump for versatile volumetric dosing that consists of two syringes e.g. dose many reactors at a time or have temperature dependant dosing. (Batch Reactor Manual 3 – Atlas Syringe Pumps (2000257)). Atlas Gravimetric Dosing: Pump a defined mass of reagent from a balance to a reactor via a controlled peristaltic pump. (Batch Reactor Software Manual 1 – Atlas and Reactor Master Software (2000262)) Atlas pH Control: Control the pH of a reaction by adding either acid and/or base as necessary to maintain a set pH value. (Batch Reactor Manual 3 – Atlas...

3.1 Atlas Potassium 3 Bar Pressure System Hardware Overview The Atlas Potassium 3 Bar Pressure System is a modular 3 bar pressure reactor system that can be controlled automatically or manually. It is available with reactor volumes of 100ml, 250ml, 500ml, 1L, 2L or 3L. All reactors can be changed in under a minute without the need for tools. The Atlas Potassium 3 Bar Pressure System is designed for applications where elevated pressures are required (e.g. hydrogenations, carbonylations etc.) or high vacuum applications. The basic system allows automatic temperature control (-80°C to...