Simple, Effective Temperature Monitoring of COVID-19 Vaccine from Distribution to Administration Monitoring Temperature During Distribution is only Half the Battle: The Last Steps are Most Critical Delivering COVID-19 vaccines to 7.8 billion people is a daunting challenge that will stretch supply chains past their limits. These vaccines in particular are very susceptible to temperature deterioration. Cold chain requirements will be different depending on whether the vaccine is being monitored in transit or at an inoculation site. Everyone is focused on the transit requirements, but what can you do to monitor temperature after the vaccine is thawed? The reality is that the last few steps before administration can be the difference between an effective or ineffective vaccine. Vaccines must be kept at the right temperature to remain effective, even a few degrees temperature difference for even a short period of time can damage the vaccine, so how do you know if they have maintained efficacy prior to administration? Monitoring Temperature During COVID-19 Vaccine Shipping As COVID-19 vaccines start shipping around the world, now is the time, to ensure temperature monitoring is in place. With the vaccine being so precious, it is critical to know that all doses administered meet efficacy standards and the patient is protected and waste is minimized. While many logistics companies, distribution facilities and even trucks have electronic temperature monitoring solutions, they are often far-far removed from the vaccine itself and not necessarily representative of the temperatures experienced. Additionally, because of their high cost and infrastructure requirements, these solutions do not transfer with the vaccines as bulk gets broken from large truckloads all the way down to individual boxes and vials at administration sites. SpotSee®’s WarmMark® time-temperature indicators are a low-cost solution that can accompany multiple packing levels from the start of a vaccine’s journey, all the way down to vaccines at an administration site. WarmMark gives you time duration of a specific temperature exposure, does not require batteries and can withstand ultra-low temperatures when applied before the vaccine is frozen. BEST PRACTICE: Apply WarmMark to the COVID-19 vaccine packaging before it is shipped or stored to monitor the vaccine’s efficacy throughout the supply chain. Low Opportunity for Failure (tightly controlled) Manufacturer Vaccine Durability (Life) Decreases Distribution Facilities High Opportunity for Failure (control is variable and distributed across thousands of sites)

Simple, Effective Temperature Monitoring of COVID-19 Vaccine Vaccine Life Declines as Temperatures and Opportunities for Failure Increase The CDC requires diligent vaccine management to minimize waste. The COVID-19 vaccine must maintain a temperature below 8°C (refrigerated) for a limited time or else the vaccine is expected to become ineffective. Thousands of administration sites have their own unique challenges. Doses of the COVID-19 vaccine must be thawed before patient administration. After thawing the vaccine, the clock starts ticking on the product shelf life and temperature excursions...