VirTis Benchmark Production Freeze Dryers John Barley, Product Manager

VirTis Benchmark - Overview • Manufactured in our Warminster, PA & Gardiner NY, USA factories • All major components are completely built in the USA, including: • Product Chamber Installed base of over 200 units worldwide, with over 20 years of continuous dependable operation

Benchmark - Overview • Production Freeze Dryers designed for a variety of life sciences applications: • Diagnostic Kits & Bulk Reagents • Bulk Collagen & Tissue Products • API (Active Pharmaceutical Ingredients)

• Industrial-grade 316L SS commercial construction – built to last • Shelf area available from 2m² to 20m² • Either bulk fixed-shelves, or, stoppering configuration

SP Scientific Benchmark Lyophilizers - Shelf Area and Clearance Model Standard Benchmark Shelf Sizes, Total Area & Clearances Other sizes available

Benchmark - Overview Design Flexibility - Configuration Options Available • Standard Round, or Square Product Chamber • External or internal ice condenser • Redundant refrigeration & vacuum systems • Rotary-vane oil vacuum pumps, or, dry scroll option

Clean room wall installation with 316L SS wall flange. Designed for easy accessibility to major components and maintenance points on the service/technical side.

Benchmark - Shelf Stack Superior Shelf Performance • Shelf Temperature Uniformity of +/- 1°C • 316L Stainless Steel Construction • Ra 25 standard interior finish • Radiant shelf above first usable shelf • Shelf Latching option for flexible processing

• Optimized shelf configurations provide maximum processing capacity = large product batch sizes with small equipment footprint • Shelf area from 2m2 to 20m2

Condenser Configurations Available • Standard External Ice Condenser with condensing plate design • Internal Ice Condenser option to save space • Condenser temperatures • - 65°C redundant (fluid) design

Benchmark - Refrigeration • Dependable 2-stage Reciprocating Refrigeration Compressors • Option for cascade refrigeration

Benchmark - Clean In Place (CIP) Option • Complete chamber coverage - riboflavin test verified • Dependable spray nozzle approach • CIP Skid - Heated Storage Tank option

Benchmark - Other Options • Isolation valve • Solvent Traps • Shelf Latching • Dry Scroll Vacuum Pump • Validation Port

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Benchmark - Controls All systems are equipped with Lyos 2.0 control system: • Process Data stored indefinitely in a secure format • Robust GE iFIX SCADA • Pirani & MKS Capacitance Manometer • Minimum 8 Product Probes • Comprehensive suite of over 25 process alarms to protect valuable product

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Benchmark - Controls Lyos-2.0 SCADA Controls - Additional Options • Automatic Batch Reports

Benchmark - Validation • Design Specifications • Lifecycle Documents with Material & Surface Finish Certifications • As-Built Drawing Package SPLCIII CATION QUAI iriCATION SYSTEM BUILD