LyoConstellation™ S30 Pilot Lyophilizer Key Features • Unmatched process accuracy and reliability • Deliver Line of Sight™ approach in cycle development & scale up using same technologies from R&D to production • Designed to conform to good instrumentation practices • Optional LyoFlux* TDLAS instrument with integrated communication with SP Hull LyoS™ 2.0 controls system software • Optional ControLyo® Nucleation Technology for improved product homogeneity and process efficiency Specifications Lowest Shelf Temperature (50 Hz / 60 Hz) Shelf Temperature Control Range Shelf Temperature Control Accuracy Shelf Pull-Down From 20° C To -40 °C Lowest Condenser Temperature Condenser Surface Area Condenser Pull-Down From 20 °C To -45 °C SP Hull LyoConstellation S30 Pilot Lyophilizer Utility Requirements Compressed Air Compressor Horsepower System Refrigerant Inert Gas For VLC / Vacuum Release Inert Gas Consumption (Full Vacuum Release) Steam For Sterilization In Place (SIP) 54.43 kg/hour (120 lbs/hour) @ 1.38-1.72 barg (20 -25 psig) Clean In Place (CIP) Water / Media Cooling Water Heat Removal Heat Output (Room), Peak Note: Performance specifications are based on SP test data from clean, dry and empty (CDE) units operating at an ambient room temperature of approximately 20 °C. SP recommends an optimum operating range of 15-25 °C (59-77 °F) with an RH of ≤ 80 % at sea level. Electrical Requirements Voltage Breaker Amperage ControLyo® Requirements (Optional) Volume To Vent Percentage Ratio (Vv/Vr) Note: Vent Volume (Vv) is the product chamber volume multiplied by 10. The volume of a standard SP Hull LyoConstellation S30 chamber is 0.71 m3 (25 ft3). Vr is the volume of the room in which the

LyoConstellation™ S30 Pilot Lyophilizer Dimensional Data FRONT VIEW Shelf Configuration Shelf Area Shelf Clearance 9 Shelves (8 Usable, 1 Radiant) Maximum Weight Shelf Dimensions (W × L) Shelf Loading Height Note: LyoFlux* TDLAS installation increases overall length by 74 cm (29 in). SP recommends a 60.7 cm (24 in) clearance around all sides of the unit for serviceability. Refrigeration Information Product Chamber Shelf Condenser Chamber AISI 316L stainless steel Isolation Valve Disc AISI 316L stainless steel AISI 316L stainless steel AISI 316L stainless steel Options / Other Considerations Surface...