3M Separation and Purification Sciences 3M Zeta Plus Depth Filters ™ High performance, scalable, single-use system

The 3M™ Zeta Plus™ Encapsulated System utilises the high performing Zeta Plus depth filter series media, including the single and dual layer. ► Positive charge is capable of reducing negatively charged DNA, endotoxins and other host cell proteins ► The 3M™ Zeta Plus™ dual layer media enhances the contaminant holding capacity of the filter media. This allows for larger particles to be trapped in the upstream zone of the more open filter media and smaller particles to be trapped in the downstream zone, reducing premature plugging and helping extend service life of the media ► Can be used for post...

Features and benefits Capsule/manifold design 3M™ Zeta Plus™ Filter Media Translucent plastic shell (standard capsules, polycarbonate shells) Ŕ Easy detection of the liquid level inside, providing real time monitoring of the filtration process Fully encapsulated shell around solid core Ŕ Eliminates the need for a stainless steel housing and the cleaning step after filtration Self guiding locking mechanism Ŕ Fast and reliable capsule-tocapsule connectivity Lenticular style capsule design Ŕ Consistency between single‑use and conventional depth filtration Bottom manifold Small 0.23m2 capsule (with...

3M™ Zeta Plus™ Encapsulated SystemThe system of choice for single-use depth filtration Ergonomically designed large filter holders Traditional depth filtration systems utilize lenticular style cartridge filters and a vertical filtration flow path to allow easy access to process liquids and efficient utilisation of filter media. However, stacking cartridges from bottom to top can be cumbersome, and dismantling the spent cartridges is often labour intensive. 4 | 3M™ Zeta Plus™ Single-Use Depth Filtration Product Portfolio

Recognising the need for a depth filtration system that is fast, easy and clean, 3M designed filter holders (Model# 16EZB) that can be pivoted between the horizontal position for loading and unloading the capsules and manifolds, and the vertical position for filtration. Allowing loading and unloading at waist height eliminates the need for operators to lift capsules above their heads and reduces the risk of fluid spills when handling spent capsules. The use of the vertical flow path allows for full media utilisation and a small system footprint during filtration. 3M™ Encapsulated System Holders,...

Innovative capsule/manifold design Two capsule configurations are available for use with the 3M™ Zeta Plus™ Encapsulated System. Ŕ Single cell and multicell capsules are available Alkaline resistant capsules available Single cells have 0.23m of filtration media Multicells have 1.6m of dual layer media or 2.5m2 of single layer media Dual stage filtration can be performed in the same holder by using an additional set of manifolds *Based on testing with 1M NaOH and 5% NaClO (bleach). Figure 2a. Nominal retention ratings for 3M™ Zeta Plus™ ZB Series Dual Layer Grades (For reference only. Retention...

The 3M™ Zeta Plus™ Encapsulated System retains the lenticular filter design and vertical flow path that are characteristics of traditional depth filtration systems. A full range of 3M™ Zeta Plus™ capsules is available from benchtop to production scale, which allows for lab scale, pilot testing and scale‑up with the same filtration media. Figure 3. The 3M™ Zeta Plus™ Encapsulated System Single-Use Depth Filtration Product Portfolio 16EZA Double layer: 1.6 m² Single layer: 2.5 m² 16EZB Double layer: 11.2 m² Single layer: 17.5 m² Process volume Surface area and scaling factor Device Scaling factor...

Table 2a. 3M™ Zeta Plus™ Laboratory Capsules: filter specifications BC25, Luer BC25, Sanitary 1 Volume of liquid required to fill capsule (experimentally measured). 2 Capsule post blow-down hold-up volume. Estimated volume of residual preconditioning flush liquid after air/gas blow-down, using water as the flush fluid and calculated by post-blow-down weight and flush fluid density. Actual amount depends upon exact blow-down conditions, media type in capsule, the number of capsules in the system, the process fluid, and loading level 8 | 3M™ Zeta Plus™ Single-Use Depth Filtration Product Portfolio...

1 Volume of liquid required to fill capsule (experimentally measured). 2 Capsule post blow-down hold-up volume. Estimated volume of residual preconditioning flush liquid after air/gas blow-down, using water as the flush fluid and calculated by post-blow-down weight and flush fluid density. Actual amount depends upon exact blow-down conditions, media type in capsule, the number of capsules in the system, the process fluid, and loading level IMPORTANT NOTICE: Always operate the filter system within the maximum differential pressure of 2.4 bar (35 psig). 3M™ Zeta Plus™ Single-Use Depth Filtration...

Table 2c. 3M™ Zeta Plus™ Production Capsules: filter specificationsConfigurationSingle cell capsule Multi-cell capsule 1 Based on testing with 1M NaOH and 5% NaClO (bleach). 2 Volume of liquid required to fill capsule (experimentally measured). 3 Capsule post blow-down hold-up volume. Estimated volume of residual preconditioning flush liquid after air/gas blow-down, using water as the flush fluid and calculated by post-blow-down weight and flush fluid density. Actual amount depends upon exact blow-down conditions, media type in capsule, the number of capsules in the system, the process fluid,...

Table 2d. 3M™ Encapsulated System Manifold specifications Upstream vent Downstream vent Manifold stop O-rings Male connector 3M™ Zeta Plus™ Encapsulated System Spacer, 34859 Configuration Dimensions (height x diameter) 50 mm x 450.85 mm Material Polypropylene Multi-use, no product contact 3M™ Zeta Plus™ Single-Use Depth Filtration Product Portfolio | 11