VarioSys®
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Flexible solutions for pharmaceutical processing

CONTENT Information Discover VarioSys® Fields of application Benefits Four partners – one system Process 1 Semi-automatic processing Dosing machines EDM Closing machine SVP Closing machine HVM Aseptic filling module for IV bags Process 2 Nest processing Modules for tub opening and denesting Module for RTU containers SFM Process 3 Bulk processing of vials Module for filling and closing vials Process 4 Automatic vial processing with freeze drying Freeze dryer Module for closing vials Process 5 Processing vials containing highly potent substances 32-33 ARM module 34-35 Add-ons

Discover VarioSys® The innovative and highly flexible VarioSys® production system for biotech and pharmaceuticals is essentially a combination of two elements: an isolator made by SKAN and machine modules made by Bausch+Ströbel and Harro Höfliger. The system has been designed to provide utmost flexibility in the production of medications by exchanging modules. The machine modules are simply slotted into place on the “lock-and-key” principle and plugged in. Pharmaceutical production can be extended by adding a suitable freeze-dryer made by GEA. VarioSys® is suitable for a wide range of...

Plug & Play Adaptable to various packaging materials Extendable modular design Modular design of the processing line GMP and FDA conforming machine design Processing toxic medications Space saving Time efficient

Four partners – one system Founded in 1968, SKAN AG today holds a leading position in the field of isolator technology for the pharmaceutical industry worldwide. Their major products include: various safety glove isolators and filling isolators for aseptic and/or highly active products, as well as complete validation/qualification documentation and service execution. For 20 years SKAN has been the leading manufacturer of isolator systems in the pharmaceutical sector. Harro Höfliger is specialized in the development of customer-oriented process and production solutions for pharmaceutical and...

Information Providing the best technical and economical answers to the challenges presented by the world market. With this clearly defined company goal in mind, Bausch+Ströbel designs, builds and sells packaging and production systems for the pharmaceutical and allied industries. From modest beginnings more than 55 years ago – with only four people – Bausch+Ströbel has developed into an international enterprise. It is now one of the leading manufacturers in pharmaceutical packaging. GEA is an expert in freeze drying technology – a partner that knows the requirements of the pharmaceutical...

SKAN VarioSys Isolator (PSI-L 2.0) Isolator The isolator provides an aseptic environment for the VarioSys® system and thus reliably protects the operating personnel and the product. This solution is suitable for processing aseptic and/or highly active substances. The new version of the isolator impresses with the patented SKANFOG® Flow System, a cleaning-friendly design and a revised air processing concept. Highest process reliability is ensured by reliable cycles with lower consumption and, above all, a significantly reduced cycle time. Great variety of possible combinations Efficient...

The newly designed SARA-XL with integrated SKANFOG® Flow technology is a safe and fast airlock for a short and gentle bio-decontamination process. The upgraded stainless-steel construction is also easy to clean. Due to its modular design, the airlock can be attached to any isolator configuration. Even when loaded, very short cycle times are possible. In addition, the principle of the single flow chamber in conjunction with the double HEPA filtered exhaust air ensure the highest level of process reliability. SKANFOG® H2O2 micro-nebulization Controlling the microbial load within A/B cleanroom...

Semi-automatic processing VarioSys® provides an ideal production environment – whether in galenics, in the lab or in small batch manufacturing. Equipped with semi-automatic machines, it can be used to fill a wide range of different containers with liquid and powder products very flexibly and efficiently. The system can easily be upgraded to a fully functional production line at any time. Quick decontamination SARA for material transfer Bench-top machine for simple and precise filling of all kinds of containers EDM Bench-top machine for closing vials with crimp or screw caps HVM Bench-top...

Dosing machines EDM Bench-top machines for simple and precise filling of all kinds of containers. Unstable containers such as cartridges, syringes barrels and test tubes can also be processed easily using transport stands. Rotary piston pump Patented single-hose peristaltic pump ViscoTec rotary displacement pump for dosing highly viscous (up to 5.000.000 mPas), shear sensitive and abrasive products Dosing with ADVANCEDfill technology Filling needle movement Vacuum-assisted dosing Automatic feedback adjustment of the dose In-process control 1 – 100 % EDM with single-hose peristaltic pump...

Closing machine SVP Bench-top machine to close cartridges and syringes with plunger stoppers (type SVP). The stopper insertion depth and insertion speed can be freely selected. Gas-flushing during stopper insertion (option) Stopper insertion by vacuum (option) Technical Specifications SVP Plunger stoppers

Closing machine HVM Bench-top machine for closing vials and cartridges with crimp caps or flip-off caps. Crimping speed and pressure as well as crimping tool lift are freely adjustable. Rotation of containers during closing Central crimping pressure adjustment Single crimping disc with servo controlled movement Technical Specifications HVM Crimp caps Flip-off caps Closing vials with crimp caps

Aseptic filling module for IV bags The system is suited for the dosing of liquids in a filling range from 50 to 2000 ml. The wide format range offers a great variety of applications. Infusion bags or larger containers as disposable product bags can be filled. Fully automatic filling process – mass flow system (Coriolis) Individual closing technology according to requirements (clamps, stoppers, welding) Completely integrated CIP/SIP (optional ) Format independent (individual retrofitting) Nitrogen flushing (integrated) Technical Specifications Working positions Dosing range Filling head with...