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Shimadzu LC/LCMS Overview

Shimadzu LC/LCMS Overview
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Shimadzu LC/LCMS Overview

Product catalog summary
Overview: This document outlines the specifications and functionalities of Shimadzu's HPLC/LCMS systems, focusing on pumps, solvent delivery, sample injection, and detection systems. It emphasizes the integration, performance, and versatility of these components in various analytical applications.
HPLC Pumps: Shimadzu HPLC pumps are controlled by system controllers and integrated into LC and LCMS software. They operate in constant flow or pressure modes, support gradient elution, and feature self-check and validation functions. Designed for analytical and semi-micro flow ranges, they are suitable for high sensitivity detection techniques and can be configured for high or low-pressure gradients.
Solvent Delivery and Selection: Known for reliability and high performance, Shimadzu HPLC modules can be controlled as stand-alone units or via system controllers/software. Models like LC-20AD and LC-20AB are highlighted for their pressure resistance and suitability for high-resolution detection techniques.
Sample Injection Systems: Various injection principles are available, including direct and loop injection, supporting different vial types and micro titer plates. Features include high-speed autoinjectors, excellent linearity, low cross-contamination, and high precision. Models like SIL-20A and SIL-HT offer expanded capacity and programmable sample pretreatment.
Detection Systems: Shimadzu offers a range of detectors, including UV/UV-VIS, fluorescence, and others, known for performance, ruggedness, and stability. Features include dual channel mode, temperature-controlled flow cells, and high sensitivity detection.
Mass Spectrometry and Chromatography Systems: The document details various systems, including LCMS-2010EV and LCMS-IT-TOF, column thermostats, fraction collection systems, system control modules, and ion chromatography systems.
LCMS-2010EV Mass Analyzer: Features a single-stage quadrupole mass analyzer with high flexibility and sensitivity, supporting ESI, APCI, and APPI sources, and includes PsiPortTM software for data review and mass-directed auto-purification.
LCMS-IT-TOF Mass Spectrometer: Combines a quadrupole ion trap with a time-of-flight analyzer for high mass accuracy and resolution, ideal for metabolomics and proteomics.
Column Thermostats: Includes air circulation ovens with a temperature range from room temperature -10 °C to 85 °C, supporting linear temperature programs and equipped with leak sensors.
Fraction Collection Systems: Controlled via software for precise fractionation, designed for micro-fractionation on MALDI-MS targets.
System Control Modules: Features communication bus modules for software control, web server access, and security features, supporting multiple instruments.
Ion Chromatography Systems: Configured for specific applications with portable options for field analysis, utilizing membrane-based suppression for high sensitivity anion analysis.
Fast LC Concept: Utilizes prominence modules for ultra-fast analysis with optimized components for fast gradient operation, featuring Shim-pack XR columns for fast analysis with moderate backpressure and high resolution.
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Catalog excerpts

Shimadzu LC/LCMS Overview-4

Several injection principles are available for sample injectionFrdieProbenaufgabe sind unterschiedliche Prinzipien etabliert direct injection 앖 the sample entersthe flow line directly. After switching to inject position, it moves without loss to the separation columnloop injection Ֆ the sample is injec-ted into the sample loop independ- ently of the flow line. When the injection valve switches to inject position, the sample is transferred into the flow line. die direkte Probenaufgabe Ֆ die Probe wird direkt in die Flusskapil- lare aufgezogen und kommt nach Umschalten der Flussrichtung verlustfrei...

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Shimadzu LC/LCMS Overview-5

fast routine autosampler (10 յL injection in 15 s)capacity of 210 standard vials (1.5 mL), 350 sample vials (1 mL), or 4micro titer plates (96 or 384 well)Օlow cross contamination built-in SCL-10A Օcontrolled by CBM-20A or SCL-10A > VP VP loop injection with external syringeunit (standard AF, AL, Ai: 500 յL syringe, optional 2.5 mL syringe; SIL-10AP: 5 mL syringe as standard)sample pretreatment (vial to vialand/or using reagent vials) Ֆ freely programmable racks for 70 vials of 4 mL or 100 vialsof 1.5 mL; optional micro titer plates or "deep well" rackՕcooled racks for 1.5 mL or 4 mL vialsoptional...

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Shimadzu LC/LCMS Overview-6

photo diode array detector (512 elements) Օinternal data buffer wavelength range 190 nm - 800 nm(dual lamp design)Օvariable slit for high resolution and high sensitivity modestandard 4 channel analog output Օlinearity 2.0 AU (ASTM) web control Օbuilt-in Holmiumoxide filter and Hg-lamp for self-check and cali- bration optional semi-micro, preparative and inert flow cellsՕPhotodiodenarray-Detektor (512 Elemente)interner Datenpuffer ՕWellenlngenbereich 190 nm - 800 nm (Deuterium- und Halogen- lampe) fluorescence detector 䕕operation wavelength range 200 nm - 650 nm (900 nm as option)wavelength accuracy...

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Shimadzu LC/LCMS Overview-7

The LCMS-2010EVsingle stage qua-drupole mass analyzer has evolved into the most flexible MS detection system for LC currently available. It delivers unprecedented performancefor a complete range of analytical challenges from integrated column switching at capillary flow rates to mass directed auto-purification at preparative flow rates.maximized sensitivity through optimized ion optics Օhigh speed mass range scanningelectronics (6,000 amu/s)supports ESI, APCI and APPI source ՕuniqueAPCIsupport for low flowrate applications (25 L/min)Օsupported by PsiPort supports analog output for triggeringan...

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Shimadzu LC/LCMS Overview-9

eine CCD-Kamera ermնglicht dieberwachung der Mikrofraktionie- rung und des aktuellen Status des Systems auf dem PC-Monitorܕuntersttzt die Mikrofraktionierungauf bis zu 18 ABI MALDIMS Targets oder 9 Bruker MALDI-MS Targets (96 oder 384 Mikrotiterplattenformat)Dieser Mikrofraktions-Sammler f얼r die Kapillar- und Nano-LC verbindet die Trennleistung und Flexibilitt einer LC mit der Identifizierungsleistung und Empfindlichkeit eines MALDI-MS. Die erforderliche MALDI-Matrix-Lsung wird vor dem Ablegen der Fraktion automatisch mit dem Eluenten gemischt. Die Einbindung des Accu- Spot in 1D- oder 2D-LC-Systeme...

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Shimadzu LC/LCMS Overview-10

These systems based on standardHPLC components are particularly configured for work in certain appli- cations areas. portable ion chromatograph for non-suppression analysis of anions or cationsՕsolvent reservoir for field analysis integrated inert pump, block heater,conductivity detector, instrument control and data processing unitՕfiles compatible with HPLC softwaretragbarer Ionen-Chromatograph fռr Non-Suppression-Analyse von Anionen oder KationenLնsungsmittelreservoir fr Analysenvor Ortintegrierte, inerte, serielle Doppel-kolbenpumpe, S앤ulenthermostat, Leitfhigkeitsdetektor und Daten- verarbeitung...

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Shimadzu LC/LCMS Overview-11

prominenceUFLC nutzt Standard-Verbindungen und -Anschlsse.schnelle Gradienten-Elution 압schnelle Injektion hohe Probenkapazitդt schnelle Detektion > Diese Systeme basieren auf Standard-HPLC-Komponenten in speziellen Konfigurationen fռr die Anforderun- gen bestimmter Applikationsgebiete. prominenceUFLC prominence Konzept fr dieultraschnelle HPLC kombiniert Module der LC-20A (wie Pumpen,Probengeber und Detektoren) mit den Shim-pack XR Sulen f줼r die ultra- schnelle Analyse. Pumpensteuerung, System-Totvolu-men, Probengeber und Detektorfluss- zellen wurden fr den schnellen Gradientenbetrieb optimiert,...

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Shimadzu LC/LCMS Overview-12

Subcontroller VP -externe Relaiskontakte -(nur FCV-20A Typen, in einem-System ist CBM-20A erforderlich)-oder manuell am Bedienpanel -(nur FCV-20A Typen) 6-port, 2-position valve to perform automatic 2-column switching, pretreatment and flow line switching2-Wege-Ventil fr automatische Sulenschaltung, Probenvorbereitung oder Fluss-Schaltung 줕can be installed in CTO-20A/AC column oven stand-alone operation (20A series only)Օcan be controlled by -CTO-20A/AC -SCL-10AVP/CBM-20A via Option -Box or Subcontroller VP -external events (20A series only; -in one system a CBM-20A is-required)-manually with...

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