Liquid Chromatograph Mass Spectrometer

EVERYTHING Sensitivity LCMS-8060 The LCMS-8060 pushes the limits of what we can see. Creating the future of LC/MS/MS analysis can mean making something work with higher sensitivity, go faster or cost less. Sometimes it means trusting answers from one day to another. 2015 LCMS-8060 A new vision in sensitivity. It simply changes everything. LCMS-8050 First mass spectrometry company to achieve a scan speed of 30,000 u/sec and 5msec polarity switching time. Increased sensitivity by 30 times. LCMS-8040 Increased sensitivity by a factor of 5 compared to the LCMS-8030. GLOBAL LAUNCH LCMS-8030 First...

LCMS-8060 Triple Quadrupole Mass Spectrometer Pushes the limits of what we can see The LCMS-8060 is a ground breaking innovation in mass spectrometry helping to transform LC/MS/MS data quality by developing a new vision of sensitivity and speed. Shimadzu is the first mass spectrometry company in the world to deliver a triple quadrupole mass spectrometer with the highest sensitivity and ultra-fast technologies to create an innovation that really matters. By redefining the ion focusing capability on the UF-Qarray™, the LCMS-8060 brings a meaningful impact to quantitative detection and opens new...

MRM chromatograms: 100 ng/mL neat standard, upper: signal comparison, lower: baseline noise comparison Built on the proven platform of the LCMS-8050, the new patented sensitivity compared to previous technologies. The chromatogram ion guides developed for the LCMS-8060 greatly improves ion for each pesticide has been magnified to show the noise has not production and collisional focusing without affecting noise. increased with a higher ion production. Innovations in ion guide The ion production, transmission and detection of three pesticides technologies not only delivers new limits of MRM sensitivity...

Inspired by the need to balance advanced high speed MS/MS detection technologies with unrivalled LC performance, we were the first mass spectrometry company in the world to deliver a scan speed of 15,000 u/sec and a polarity switching speed of 15 msec. In the LCMS-8060 the scan speed is now increased to 30,000 u/sec and a polarity switching speed of 5 msec making a real difference to working better and faster. Loop time (msec) Fast polarity switching Dwell time Fast cycle time helps to detect more compounds with greater confidence and precision. Faster polarity switching time maximizes dwell...

High-sensitivity quantitation of intact catecholamines (CAs) in human plasma. In clinical research, plasma catecholamines and their O-methylated metabolites (metanephrines) are measured as biomarkers for diseases such as hypertension, pheochromocytoma or neuroblastoma. It is a challenging assay as the low physiological levels of CAs, physicochemical properties, and potential interferences require high sensitivity and specificity. We developed a SPE-LC/MS/MS assay by using LCMS-8060 to detect catecholamines at ultra-high sensitivity without matrix interferences. As the measurement cycle time was...

Expand your capabilities in quantitation Ultra sensitive detection in bioanalysis Bringing together ultra fast scanning technologies with high sensitivity pushes the limits of what we can see. The LCMS-8060 is built for high data quality and drives confidence and consistency 24/7.

The triple quadrupole LCMS-8060 has an advanced ion guide design to increase ion production and detection and makes a meaningful impact on high sensitivity detection. High- S e ns it ivit y Quant it at io n o f Ve r a p a mi l i n P l a s m a Verapamil in plasma; 100 ag on column Precision and accuracy of verapamil ESI positive; m/z 455.40 > 165.00 CE: -27V Actual Conc. (ng/mL) Calculated Conc. (ng/mL) %RSD 5.08% (n=10) Linear dynamic range 0.1 pg/mL to 50 ng/mL • Verapamil spiked into a plasma crash sample can be quantified at 100 ag on column with a precision of 5.08% for multiple injections...

Expand your capabilities in quantitation Ultra sensitive peptide analysis and lipid profiling Advanced design, fast workflows and added business value help the LCMS-8060 deliver on a broad range of applications. The challenge in peptide analysis and lipid profiling is to generate high data quality in complex samples. For research use only. Not for use in diagnostic procedures.

High sensitivity and fast scanning capabilities has opened up new workflows for quantitative proteomics. In the detection of the tryptic peptide AFVFPK (from C-reactive protein, CRP) as a biomarker for inflammation 3 mg/L is reported as an average level of CRP in plasma. The LCMS-8060 delivers a highly sensitive detection of AFVFPK with the lowest calibration curve point at 0.008 mg/L. Synthetic peptide AFVFPK in neat solution Spiked conc. (mg/L, in plasma) Quantitative results of AFVFPR (isotope labeled peptide) spiked into trypic digested plasma Chromatogram of trypic digested peptide derived...

Expand your capabilities on Quan/Qual Quan/Qual approaches using ultra fast capabilities Shimadzu is a global leader in ultra fast capabilities in mass spectrometry creating methods that are designed to overcome real-world obstacles and deliver better data.

Ultra fast capabilities help to reshape workflows and help productivity by bringing together definitive quantitation and information rich MS/MS spectra in a single analysis. The LCMS-8060 can quickly switch between a full scan analysis and precise quantitation using the Synchronized Survey Scan™ (SSS) mode. This mode automatically performs product ion scanning once a pre-defined threshold has been exceeded. Qual/Quan methods can support a maximum of 1000 events in a single SSS methods. Data acquisition method setting of Synchronized Survey Scan using MRM as survey and product ion scan as dependent...

Engineered for Robustness and Easy Operation/Maintenance The robustness of the LCMS-8060 and modified ion optics was a deuterated internal standard (alprazolam-d5) the RSD was 3.5%. also assessed by injecting 2400 samples of femto-gram levels of As part of the robustness test the vacuum system was vented to alprazolam spiked into protein-precipitated human plasma extracts model a transient power failure with no effect on signal response over a 6 day period (over 400 samples were injected each day). or baseline noise level. The RSD of peak area response was 5% over this test period, using ×104...