Liquid Chromatograph Mass Spectrometer

Sensitivity Beyond Comparison Continuing the evolution of Shimadzu's UF technology, Shimadzu introduces the LCMS-8050 triple quadrupole mass spectrometer, offering unparalleled measurement speeds and high-sensitivity performance. High-sensitivity quantitation delivered at high speed Multi-component analysis performed more rapidly Simultaneous qualitative and quantitative analyses The high performance of the LCMS-8050 defies expectations, redefining high-sensitivity, high-speed analysis.

High-Sensitivity & High-Speed Positive/Negative Ionization Switching in 5 msec When performing simultaneous positive/negative ion measurements of multiple components, the proper acquisition of sharp UHPLC peaks depends on rapid polarity switching. The LCMS-8050 minimizes losses due to polarity switching and ensures the collection of sufficient data points for even the narrow peaks obtained with UHPLC, recording accurate peak shapes and allowing excellent reproducibility. • Easily obtains over 20 points per peak with UHPLC. • Achieves excellent reproducibility even at the lowest calibration level. •...

U SC0nning High-Sensitivity & High-Speed Scanning at 30,000 u/sec Simultaneous Quantitative and Qualitative Analysis Simultaneous High-Speed Screening of 12 Toxicological Drugs The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Acquisition occurs so rapidly that MS/MS scans and MRM measurements can be performed concurrently while maintaining quantitative accuracy. MS/MS scans are usable and reliable because even at 30,000 u/sec, Shimadzu uses a 0.1 u scan step. JliL. 13 points ' \ %RSD (n=3) MRM Triggered Product Ion...

UFsensitivity High Sensitivity for Trace Quantitative Analysis Scientists who demand trace-level quantitation will benefit from a newly designed heated ESI probe and a new high-efficiency CID cell, the UFsweeper III. These technological improvements combined with Shimadzu’s patented ion optics system deliver durable high-sensitivity performance.

UFsensitivity UF-MRM Heated ESI Probe In order to improve desolvation efficiency, the newly developed heated ESI probe combines a high-temperature gas with the nebulizer spray, assisting in the desolvation of large droplets and facilitating ionization. This development allows for high-sensitivity analysis of a wide range of target compounds. Signal intensity: 30 X improvement Excellent Reproducibility Even at Attogram (ag) Levels Both sensitivity and reproducibility are essential when establishing low limits of quantitation. High-precision quantitative results obtained with the LCMS-8050 in the...

UFswitching Polarity Switching Technology with No Compromise in Quality or Sensitivity Ultra-high speed positive/negative ionization switching technology [ UFswitching ] maintains constant quality and sensitivity with no loss of quantitative accuracy. Laboratories can now use a single method for both positive and negative ions, increasing sample throughput and saving method development time.

Only 5 msec to Achieve Stable Quantitative Accuracy with Positive/Negative Ionization Switching Ion intensity is maintained even when performing polarity switching at ultra-high speed. The LCMS-8050 uses unique high-voltage power supply technology to achieve an ultra-high-speed positive/negative ionization switching time of just 5 msec. The LCMS-8050 is also the only instrument of its type to maintain ion intensity even when performing polarity switching at ultra-high speed, yielding consistent, reproducible data. Excellent quantitative results can be obtained from UHPLC peaks no more than 2-3...

UFscanning Simultaneous, Highly Reliable Quantitative and Qualitative Analysis Employing ultra-high-speed scan technology [ UFscanning ], the LCMS-8050 maintains spectrum quality at any scan speed. Perform quantitative and qualitative analysis simultaneously with a high-speed scan rate of 30,000 u/sec.

UFsensitivity UFswitching Maintain Sensitivity and Mass Accuracy Even at 30,000 u/sec By controlling the voltage applied to the quadrupoles according to scan speed and m/z, the LCMS-8050 achieves superior ion transmission at any scan speed. And because Shimadzu maintains data collection at 0.1 u intervals, high-quality mass spectra are obtained without loss of sensitivity or mass accuracy. Top of peak is not defined resulting in a large variation in the m/z determination. Proper data collection rate allows accurate determination of m/z value. Variation in m/z Caused by Different Sampling Intervals...

UF Technologies Combine Sensitivity and High Speed The LCMS-8050 combines the following technologies to ensure highly sensitive, high-speed performance: [ UFsensitivity ] achieves high-sensitivity performance utilizing a new heated ESI probe and new UFsweeper III collision cell. [ UFswitching ] high-speed positive/negative ionization switching and high-speed MRM [ UF-MRM ] maintain data quality and sensitivity. [ UFscanning ] high-speed scan rate obtains high-quality mass spectra, even during high-speed analysis. Heated ESI Probe High-temperature gas supplements the nebulizer gas, improving desolvation...

UFsweeper III Collision Cell A high-sensitivity, high-speed collision cell, the proprietary UFsweeper III accelerates ions out of the collision cell without loss of momentum. Achieving fast sweeping on successive scans, it offers twice the CID efficiency of UFsweeper II, maintains signal intensity, and suppresses crosstalk, even for high-speed or simultaneous multi-component analysis. UFsensitivity UFswitching UF-MRM UFsweeper III high-speed ion transport technology minimizes ion loss even at a dwell time of 0.8 msec. High-speed MRM transitions up to 555 ch/sec accelerate laboratory throughput...

Engineered for Robustness and Easy Operation/Maintenance Maintains High Sensitivity Even During Successive Demanding Analyses In addition to speed and sensitivity, Shimadzu designed the LCMS-8050 for robustness to meet the most demanding laboratory requirements and most difficult matrices. The figure below plots the area results from 1000 consecutive analyses of a deproteinized blood plasma sample spiked with alprazolam. The LCMS-8050 achieves excellent reproducibility with a 4.59 % RSD for the area results over the 1000 analyses. 50 pg/mL alprazolam in plasma m/z 309.05 > 281.15 Area % RSD =...