Liquid Chromatograph Mass Spectrometer

Seamless integration with LC by design Superior detection for added confidence Streamlined operation for cost efficiency The LCMS-2050 provides both high speed and high sensitivity analysis even in a small design. We have achieved the utmost in both miniaturization and high performance with Shimadzu's technology cultivated over many years of MS development. A single platform, a single solution for LC detection, the LCMS-2050 has the power to deliver better results with incredible simplicity and unparalleled robustness. It may be small but the design and capability of the new single quadrupole...

Seamless integration with LC by design To simplify its use as the ultimate LC detector, the LCMS-2050 features uncompromising instrument design, instrument control, and data analysis. Seamless Connectivity with Shimadzu LC Systems The small footprint of the LCMS-2050 creates the flexibility to adapt to different needs. As with other LC detectors, It can be integrated into any Shimadzu LC architecture whether it is a high throughput analytical system, a preparative LC with fraction collection, or even a legacy model. Nexera™ series Quick Startup Nexera Prep The vacuum system is ready in as little...

Easy Parameter Settings for Seamless Operation Mass spectrometers are often considered difficult to use, but the advanced engineering of the LCMS-2050 makes it as simple to use as other LC detectors. Only the simplest of acquisition parameters are required to obtain reliable and sensitive detection. Adding MS to Complement and Confirm Optical Detection UV-PDA and MS are orthogonal technologies each having their own strengths. MS detectors are generally more sensitive than optical detectors, and moreover enable selective detection of compounds by their masses. For this reason, MS detectors can...

Superior detection for added confidence High-speed performance is a hallmark of Shimadzu LCMS detectors, and the LCMS-2050 is no exception. Industry leading scan speeds and polarity switching speed have now been incorporated into a miniaturized single quadrupole LCMS instrument in addition to excellent ionization capability and a wide mass range. Wide Mass Range The wide mass range of the LCMS-2050 is a powerful tool for molecular weight determination of large molecules such as oligonucleotides, peptides, proteins, polymers, and more. As an example, analysis of an antisense oligonucleotide, nusinersen,...

The LCMS-2050 is equipped with the newly developed Heated Dual Ion Source (Heated DUIS™) as the standard configuration. This hybrid source combined the benefits of electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI), two orthogonal techniques widely used in mass spectrometry. The result is excellent sensitivity achieved for compounds for a diverse range of chemical properties, including low-polarity compounds. Convensional MS detectors will require switching ion sources from ESI to APCI to detect low-polarity compounds such as quintozene and trimellitic anhydride....

Analyzing More Compounds Than Before Int.×10,000 HPLC is widely used for the analysis of sugars. However, sugars do not absorb light in the UV-VIS range, so they cannot be detected with common LC-UV detectors. Using mass spectrometry, sugars can be analyzed with high sensitivity. The figure below shows the mass chromatograms obtained from an analysis of five sugar components using the sensitivity qualitative and quantitative analyses of Maltose Lactose Mass chromatograms for fructose and glucose (monosaccharides in negative ion MS detection) and sucrose, maltose and lactose (disaccharides in...

Improved Detection for Fast Chromatography Compounds can be detected with good sensitivity by the LCMS-2050 even when minimal UV adsorption prevents them from being analyzed by LC-UV. In addition, the LCMS-2050 can detect both positive and negative ions quickly with a scan speed of 15,000 u/sec, and 10 msec positive/negative polarity switching. The LCMS-2050 is therefore the ideal detector for UHPLC chromatography and high-throughput laboratories. UV Chromatogram (Top) and Mass Chromatogram (Bottom) for Five Pharmaceutical Components The superiority of MS detection over UV detection is demonstrated...

Streamlined operation for cost efficiency In addition to saving on laboratory space, the LCMS-2050 contributes to significant energy savings and improved operational efficiency. In particular, the instrument is replete with technology and functions to ensure that even users unfamiliar with mass spectrometers can easily and efficiently proceed with data acquisition. The LCMS-2050 enhances laboratory productivity by saving energy and saving space, and then delivers maximum results with minimum effort. Space Savings The LCMS-2050 is similar in size and stackable with LC units so it can be added...

Easy Maintenance Like all other MS products by Shimadzu, the ionization interface of the LCMS-2050 has a simple, accessible design that minimizes the efforts needed to maintain the instrument in a good state. The desolvation line (DL) that transfers the sample into the vacuum chamber can be replaced without using tools and without breaking the vacuum. Quick and easy maintenance means less downtime, labor, and cost. Remove the heater flange. Remove the DL assembly from the back of the heater flange. Environmental Responsibility 240 V specifications, and its Ecology Mode function (page 12), the...

Total Support from Data Acquisition to Data Analysis with an Integrated Operating Environment The LabSolutions LCMS workstation for the LCMS-2050 delivers streamlined instrument control and sophisticated data analysis using Analytical Intelligence. It also foresees and addressees the increase in demand for energy savings. In addition, the LCMS-2050 is compatible with Open Solution, which can further improve the efficiency of laboratory work. This function checks the usage of the system, and if it has not been used for a set time, it shuts down automatically. The following three shutdown modes...