LC/MS/MS

LC/MS/MS

LC/MS/MS

Product catalog summary
Overview: The document describes a system designed to enhance the efficiency of simultaneous LC/MS/MS analysis methods for toxicology. It allows users to bypass time-consuming steps like separation condition considerations and MS parameter optimization, enabling rapid analysis of 231 compounds, including drugs of abuse and sedatives, in under 15 minutes.
Specifications: The system includes optimized conditions for synchronized survey scans used in screening measurements, with a focus on the product ion spectrum as a threshold for intensity in MRM. It supports semi-quantitation through calibration curves based on internal standards, allowing for simple quantitative analysis post-analysis.
Procedures: The system employs a pretreatment method based on the QuEChERS method for comprehensive compound recovery from biological samples. Qualitative analysis can be performed using a spectral library during data processing.
Data Analysis: Using LabSolutions Insight Library Screening, users can access quantitative results, library search results, MS chromatograms, MS/MS spectra, and structural formulas.
Requirements: LabSolutions LCMS Ver. 5.109 or later and LabSolutions Insight Ver. 3.8SP1 or later are required. Differences in quantitative values may occur based on equipment specifics, and accurate quantitation requires a calibration curve method with appropriate standard samples.
Registered Compounds: The system includes 231 compounds such as illegal drugs, sedatives, psychotropic drugs, and medical drugs.
Remarks and Precautions: The document emphasizes the importance of using multifaceted information for accurate compound identification and notes that the publication is for research use only, not for diagnostic procedures.
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Catalog excerpts

LC/MS/MS-1

LC/MS/MS Rapid Toxicology Screening System Ver.3 Library info for 231 compounds common in toxicology This system improves the efficiency of simultaneous LC/MS/MS analysis methods by allowing the user to start analysis without time-consuming steps such as consideration of separation conditions and MS parameter optimization. Rapid simultaneous analysis methods with analysis times under 15 mins are included for 231 compounds including drugs of abuse, psychoneurotic drugs and sedatives. The system also provides optimised conditions for synchronised survey scans used in screening measurements (conditions adopted for the product ion spectrum as a threshold value for the intensity in MRM). Example of data analysis using LabSolutions Insight™ Library Screening: Using LabSolutions Insight Library Screening, you can check all of the following: Total solution including semi-quantitation For each compound in the method, calibration curve information based on internal standards is available, so it is possible to obtain simple quantitative values after analysis. Using a pretreatment method based on the QuEChERS method*, it is possible to comprehensively recover compounds from biological samples. Qualitative analysis using the spectral library can be carried out during the data processing stage. In other words, the system provides a total solution encompassing pretreatment, analysis and data processing. Pretreatment using the Micro Volume QuEChERS Kit (1) Add the sample (2) Separate with a centrifuge (3) Transfer the supernatant to a vial (1) Quantitative results (2) Library search results (3) MS chromatogram (4) MS/MS spectra (5) Structural formula (1) * For details of the pretreatment method, please refer to the website by scanning the QR code.

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LC/MS/MS-2

LC/MS/MS Rapid Toxicology Screening System Ver. 3 List of registered compounds: 231 compounds including illegal drugs, sedatives, psychotropic drugs and medical drugs associated with many real-life cases. IS Diazepam-D5 (Positive) IS_Phenobarbital-D5 (negative) 7-Aminoclonazepam 7-Aminoflunitrazepam 7-Aminonimetazepam 7-Aminonitrazepam 8-Hydroxyetizolam (M-III) Acetaminophen Aconitine Alfa-methyltryptamine Allylisopropylacetylurea alpha-Hydroxyalprazolam alpha-Hydroxymidazolam alpha-Hydroxytriazolam Alprazolam Amitriptyline Amlodipine Amobarbital Amoxapine Amphetamine Ampicillin Aripiprazole...

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All Shimadzu France catalogs and technical brochures

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.