LC/MS/MS Forensic Toxicology Database The database includes information on drugs of abuse, hypnotics, psychotropics, pesticides, prescription drugs and natural toxins. Simplified Acquisition and Identification The Forensic Toxicology Database includes optimized LC-MS/MS data acquisition parameters and a library database to help clinical and forensic researchers build screening and quantitation methods quickly, simplifying method development. MRM & Spectral Library database contains information on more than 2,500 compounds The spectral library database is built using two separation conditions (ODS and Biphenyl). Both methods have information on clinical and forensic compounds of interest in routine analysis. The ODS method contains information on 1,250 compounds and the Biphenyl method contains 1,281 Enhanced identification by merged spectrum Each certified reference material was acquired with three different collision energies to generate an information-rich merged-CE spectrum which can be used in library matching and compound verification. Matching with a merged-CE spectrum library can be a powerful tool to identify compounds with a library score. compounds. Compound datasheet includes: monoisotopic mass, RT, CAS number, formula and compound class. This package provides Synchronized Survey Scan parameters (MRM parameters, MRM intensity threshold and triggered product ion scan parameters) optimized for screening analysis. Analytical Conditions for ODS column Analytical column : Phenomenex Kinetex XB-C18 (2.1 mmI.D. x 100 mmL., 2.6um) Guard column : Phenomenex SecurityGuard ULTRA C18 2.1mmID Mobile phase A : 10 mmol/L ammonium formate + 0.1% formic acid – water Mobile phase B : 10 mmol/L ammonium formate + 0.1% formic acid – methanol Flow rate : 0.3 mL / min Column temp. : 40 °C Analytical time : 15 min Analytical Conditions for Biphenyl column Analytical column : Restek Raptor Biphenyl (2.1 mmI.D. x 100 mmL., 2.7um) Mobile phase A : 2 mmol/L ammonium formate + 0.002% formic acid – water Mobile phase B : 2 mmol/L ammonium formate + 0.002% formic acid – methanol Flow rate : 0.3 mL/min (0.5 mL/min from 11 min to 14 min) Column temp. : 50 °C Analytical time

Method Creation by "Compound List Creation Tool" To accelerate customized method development, the 'Compound List Creation Tool' can be used to select specific panels of targets from the library for analysis by LC-MS/MS. Creation of text file Import file into LabSolutions Synchronized Survey Scan (Including three Product Ion Scan events with three different CE) Compound Identification by Merged Spectra Merged Spectra using three MS/MS spectra with three different CE help to increase the confidence in reporting results by using library searchable spectra. Merged Spectrum MS/MS Spectra with three...