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HPLC toxicological analysis modul prominence TOX.I.S. II

HPLC toxicological analysis modul prominence TOX.I.S. II

Product catalog summary

Overview: The document discusses the Shimadzu HPLC modules, specifically the TOX.I.S. II system, which is designed for toxicological analysis of body fluids. It highlights the system's reliability, high performance, and flexibility in various applications, particularly in identifying acute poisoning, drug abuse, and illegal substance use.

Specifications: The TOX.I.S. II system utilizes HPLC hardware modules with a special column-switching procedure for sample pretreatment. It includes photodiode-array detection for identifying toxic substances based on retention time and UV spectra. The system is fully automated and supports systematic toxicological analysis (STA).

Procedures: The analysis involves centrifuging urine samples, adding an internal standard, and transferring samples to an extraction column. After removing proteins and larger molecules, the sample is eluted and transferred to the analytical separation system. Peaks are identified through retention times and library comparison, generating a report with detailed information.

Standards and Recommendations: The system comes with a standard operating procedure for daily validation and performance checks. It is recommended to use comprehensive data collections and continuously update the UV spectral library to accurately identify new drug compounds.

Application Kits: Application kits from Recipe® are available, including testing solutions and internal standards for basic and pharmaceutical drugs. The UVTOX spectral library, developed over 15 years, is used for identifying toxic substances in various matrices.

Limitations: The system is for research use only and not for diagnostic procedures. It may not identify substances with concentrations under 100 ng/mL in urine or serum, such as THC.

Company Information: Shimadzu Corporation, founded in 1875, is a leader in advanced technologies with a global network for sales, service, and support. The document includes contact information for Shimadzu Europa GmbH.

Catalog excerpts

HPLC toxicological analysis modul prominence TOX.I.S. II-2

Toxicological analysis Shimadzu HPLC modules stand for reliability and high performance in many application fields. Following the approach of stepwise system control, most of the instruments can be used as stand-alone solution, controlled by a system controller or by software. Continuous research and development on HPLC components guarantees high performance and optimizes routine operation. Analysis without delay Toxicological analysis of body fluids is a major task for identifying acute poisoning*, drug abuse or the use of illegal substances. These analyses are very demanding on time and resources...

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HPLC toxicological analysis modul prominence TOX.I.S. II-3

prominence TOX.I.S. II – UV spectral library 350 300 Library search result “morphine peak” Basic Drug Application: Example of the detection of MDA, 6-acetylmorphine, MDMA, methadone, morphine, codeine and EDDP. (MDA = 3.4-methylenedioxyamphetamine; MDMA = 3.4-methylenedioxymetamphetamine; EDDP = 2-ethylidene1.5-dimethyl-3.3-diphenylpyrrolidine). Chromatogram of ClinTest® Test Solution 150 UVTOX – UV spectral library of 3.260 toxic compounds Pharmaceutical Drug Application Doxylamine: 12.0 min, Norclozapine: 17.5 min, Doxepine: 23.7 min, Carbamazepine: 27.1 min, Oxazepam: 28.9 min, Temazepam:...

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HPLC toxicological analysis modul prominence TOX.I.S. II-4

prominence TOX.I.S. II system ClinRep® Reagent Kit for Basic Drugs in Urine (Recipe order no. 60000) ClinRep® Reagent Kit Pharmaceuticals in Urine (Recipe order no. 60100) ClinRep® Reagent Kit Pharmaceuticals in Plasma (Recipe order no. 60200) + Accessories (Guard-Column, Column, SPE-Column etc.) *Substances which have normally under intoxication a concentration under 100 ng/mL in urin or serum, e. g. THC, could not be identified. Part Number **The application was developed in cooperation with Dr. Lena Schönberg, Dr. Thomas Grobosch and Dr. Dagmar Lampe Labor Berlin - Charité Vivantes GmbH, Laboratory...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.

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