Method Development

Maximizing Efficiency for HPLC Method Development The Nexera Method Scouting System design is based on the Nexera next-generation ultra high performance liquid chromatograph. It is equipped with two quaternary solvent pumps, a high pressure resistant column switching valve and the dedicated Method Scouting Solution control software to enable automated, quick and simple column and solvent screening. In combination with DryLab®4 HPLC modeling software for strategic method optimization and the VALIDAT toolbox for method validation this system provides an all-round solution for efficent and highly...

The Nexera Method Scouting System The Nexera Method Scouting System is based on the Nexera UHPLC excellent injection repeatability as well as virtually no carry-over. with its established outstanding performance for ultra-high speed As a result, reliable method scouting data is efficiently produced. analysis. It features stable solvent delivery at ultra-high pressure, Flow Channel Selection Valve (FCV-34AH) Photodiode Array Detector Basic Configuration of the Nexera Method Scouting System The Nexera Method Scouting System provides a choice of six stationary phases, by adopting the newly developed...

The Method Scouting Solution Software The Nexera Method Scouting Solution supports fast and secure operation of the Nexera Method Scouting System. It offers a graphical user interface to simplify the system set up, as well as Automation of System Operation pre-configured system settings conforming to laboratory policies, to provide reliable data while minimizing the risk of human error. Purging the system with a new mobile phase and equilibration after switching to a new column are key issues in setting up an automated method scouting run. With the Method Scouting Solution Software, auto purge...

Graphical User Interface to Support System Set Up Fie Tool Verelan Info F,l(rjIIU _fCalL»n)Jp*»"P*Op^'I,oBj_.ln,- Core ,_iF.nii Cone i Gragiertf Pattern During a method scouting run a variety of stationary and mobile phases are used in a number of different gradient experiments. The Method Scouting Solution Software calculates the amount of solvent and sample required based on the automatically generated scouting batch, to avoid any shortages during the course of the Furthermore, upper pressure and temperature limits are automati- cally controlled based on the column specifications registered...

DryLab® 4 - HPLC Modeling Software The use of DryLab® 4 computer simulation software to predict retention behavior and optimize chromatographic separations is an extremely powerful tool in HPLC method development. For over 25 years, DryLab® has been employed successfully in the separa- tion of small molecule pharmaceuticals of widely differing polari- ties, as well as peptides, protein mixtures, metabolites, complex mixtures of active compounds from plant origin or environmental pollutants - just to name a few of its many application fields. With its user-friendly design and the LabSolutions...

One- Two- and Three-Dimensional Models One of the main advantages of the DryLab® 4 software – apart from its excellent prediction accuracy – is the flexibility of the Design Space: it can be used to model isocratic or gradient separations as a function of multiple variables, such as % organic solvent, gradient time, temperature, pH or ionic strength in a continuous way. In addition to one-dimensional modeling, simultaneous variation of any two and even three separation conditions is possible, allowing to investigate the effect of changes in e.g. 1990 gradient time versus pH and temperature in...

VALIDAT – The Solution for Method Validation Throughout more than twenty years VALIDAT established itself as the leading software solution for efficient method validation. Today VALIDAT supports validation documentation according to all important regulations (ISO/DIN/USP/ICH/JP/FDA/GxP etc.) for our customers in pharmaceutical, chemical, or biotechnical industries: reliable, professional and secure. VALIDAT with its integrated workflow and LabSolutions CDS interface can help to save up to 70 percent of time and costs in method validation! Your time savings by using VALIDAT with VALIDAT Validation...

VALIDAT has been designed according to the strict regulations of DIN EN ISO 9001:2008 and GAMP. In this, two principles have been given priority: A variety of guidelines and regulations translated into checkpoints Integration in Your Infrastructure It is easy and effortless to adjust VALIDAT to the infrastructure of any company and workflow. Contract laboratory with a limited amount of users or large pharmaceutical company with more than hundreds of users worldwide, VALIDAT offers a variety of iCD. offers assistance and support at each stage of a project. Experienced employees will help on-site...

Modeling Software: DryLab®, 3D-Resolution Map, Robustness Module, HPLC Knowledge Management Protocoll UHPLC Method Development Consulting & Training Schneegloeckchenstrasse 47 10407 Berlin, Germany Tel.: +49 - (0)30 - 42 15 59-0 Fax: +49 - (0)30 - 42 15 59-99 [email protected] www.molnar-institute.com iCD. Vertriebs GmbH Augustinusstr. 9d 50226 Frechen, Germany Tel.: +49 - (0)2234 - 96 634-0 [email protected] www.icd.eu Company names, product/service names and logos used in this publication are trademarks and trade names of Shimadzu Corporation or its affiliates, whether or not they are used...