Auto Purification/Powderization System Crude2Pure
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State-of-the-Art Auto Purification/Powderization System

P ur ific a t io n /powderization after re te n tio n a n d co n ce n tra tio n o f fra ctio n s o f ta r g et c omp o u n d s obtained by a preparat iv e L C sy ste m “Crude2Pure” System with a completely new way When purifying target compounds from extracts of natural products and synthetic substances via preparative LC, powderization of the target compounds of the fraction is an important process. Ordinarily, it takes time to purify and powderize the target compounds obtained by the preparative LC. It is also difficult to recover high-purity powder. The Crude2Pure system, which is based...

Crude2Pure Recovery System Quick and high-purity powderization of fractions State-of-the-Art Auto Purification/Powderization System Purification/ Powderization Recovery of only target compounds in high-purity powder Removing Solvent-derived Components and Recovery of High-Purity Powder Fast Powderization of Liquid Fractions Setting Samples at Any Time —Open Access

Crude2Pure Automated Purification LC System™ The Crude2Pure system consists of a trapping system equipped with a dedicated Shim-pack C2P-H column for trapping and concentrating the target compound, and a recovery system that automatically powderizes and recovers the trapping target compound. Single and multi-system configurations are available to meet specific operational requirements. Retention and Concentration of Compounds —Crude2Pure Trapping System— Ordinarily, when removing solvents, it is necessary to with a wide range of organic solvents and pH conditions, evaluate detailed...

Flexible System Configurations Basic Crude2Pure System (Single Recovery System) This is the simplest Crude2Pure system. The trapping system can process up to four samples and the recovery system two samples. (Expansion to a multi system is possible.) Trapping System Recovery System Single Recovery System Multi Recovery System Supporting Multi-sample Processing This is recommended for multi-sample processing. The sample concentrated by the single trapping system is processed continuously by the multi recovery system. The recovery system accommodates up to 48 samples. The dedicated software,...

Removing Solvent-derived Components and Recovery of High-Purity Powder Easily remove counter ion and dif ficult volatile solvent In solvent removal with a centrifugal concentrator, which is a included in fractionated liquid from the preparative LC system and conventional method, it is difficult to remove solvent if mobile recover the sample as powder. phase includes components which generate counter ions such as By method selection at the time of recovery, it is possible to trifluoroacetate or difficult volatile components such as dimethyl remove mobile phase components and make powder in...

Fa s t P owderi zati on of Li qu id F r a c t ions Rapid purification and powderization of target compounds More than 8 hours were necessary to remove solvents of target compounds by increasing the moisture content. rich-liquid sample by a centrifugal concentrator. In addition, in The Crude2Pure system can powderize in only three to four hours concentrating process, there was a risk of decomposition of the and it is possible to reduce the risk of decomposition by moisture. Sample directly after synthesis Conventional Method Preparative LCMS Preparative LCMS Frac tionation Low-purity powdery...

Setting Samples at Any Time —Open Access— The Crude2Pure is operated by the dedicated Open Solution instrument at any time. There is virtually no risk of influence of Crude2Pure software. The software automatically selects condition sample carryover to the sample which was set already. settings. In addition to user support functionality such as login The software can accommodate everything from personal systems control functions, column history log function is provided to allow to multi-user open access environments. operation by multiple analysts. Samples can be set on the Share Sys tems...

Requires just three steps from login to start both trapping and recovery. Trapping information and other conditions can be configured in an interactive format. There is no need to learn special software operations. The same type of operations are used for trapping and recovery, so anyone can easily perform automatic purification. Enter the number of compounds and other trapping information STEP 2 STEP 3 Open Solution C2P Recovery sdshimaozu Start recovery The system is controlled by LabSolutions Automated Purification System. Trapping conditions and other detailed settings are performed...

Requires trapping columns, trapping column racks, powder vials, and a PC, which can be obtained separately. The PC and Open Solution Crude2Pure can be shared by the trapping system and recovery system.

Trapping Module State-of-the-Art Auto Purification/Powderization System 11

Preparative LC Systems The preparative LC systems are optimal for preparative LC before online powderization via Crude2Pure. The preparative LC systems provide high-purity preparative fractionation utilizing a diverse range of units. These include the LC-20AP preparative pump, which covers a wide range of flow rates from the low flow rate region (for evaluating preparative conditions) to large-volume fractionation, as well as the FRC-10A, a fraction collector equipped with an automated peak fractionation function. The analysis/preparative switching system enables a single system to be used...