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Resolute® RCC MU

Resolute® RCC MU
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Product Datasheet Implementation of Membrane Chromatography Based on Rapid Cycling Chromatography (RCC) Product Information The Resolute® RCC MU is a liquid chromatography system intended for small scale production and process development in purification of biomolecules. Designed to achieve optimum purification of mAbs, ADCs, vaccines, viral vectors, and recombinant proteins, the system provides a tailored design and configuration for the implementation of membrane chromatography based on Rapid Cycling Chromatography (RCC). Compared to traditional and multi-column chromatography in mAb bioprocessing, RCC offers extremely high productivity and enables a consistent performance together with Sartobind® membrane chromatography products. This optimized skid addresses the challenges of running many cycles in a short time – with fast flow rates, rapid buffer changes, data handling and real time analytics powered by Umetrics® and supported by full-spectrum pre-post

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Features and Benefits RCC Solution Efficient processing by quick Time and cost saving Reliable process control and Consistency of product quality Two modes for bind-elute and flow-through (Optimized system, device membrane) Rotatable HMI, keyboard and touchscreen Positive displacement pump with low pulsation Small void volume (overall system: 190 mL) ramp-up, less back mixing and concentration dilution Defined fluid inlet: Mixing point of feed and buffer lines close to the membrane adsorber Optimized valve with very short advanced analytics Full-spectrum UV sensors Real-time monitoring and...

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Technical Specifications Process Utilities Requirements Tubing material Polypropylene, stainless steel 316L Stainless steel 304, painted stainless steel (powder coating) Gasket Material & other Wetted Part PPSU Radel®, stainless steel (316L), quartz, glass, ceramic, PP, PTFE, PEEK, EPDM, EPDM-PP or platinum silicon Electrical cabinet Painted stainless steel (powder coating) Tubing internal roughness Electro polished <0.6 μm Ra (71 μ-inches Ra) Valves internal roughness Pumps internal roughness Electro polished <0.6 μm Ra (71 μ-inches Ra) Frame external roughness Grit 200 (about 1.6 μm Ra...

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Technical Specifications Selection of Membrane Adsorbers Bind-Elute Sartobind® Q and S Membrane volume (MV) Nominal membrane area Maximum pressure bar (MPa, psig) at 20 °C Maximum pressure during venting bar (MPa, psig) at 20 °C Nominal membrane area Maximum pressure bar (MPa, psig) at 20 °C Maximum pressure during venting bar (MPa, psig) at 20 °C Nominal membrane area Maximum pressure bar (MPa, psig) at 20 °C Maximum pressure during venting bar (MPa, psig) at 20 °C Nominal membrane area Maximum pressure bar (MPa, psig) at 20 °C Maximum pressure during venting bar (MPa, psig) at 20 °C

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Ordering Information Configuration Capture The Resolute® RCC MU system can be mechanically and electrically configured as a batch to be used for capture. Description Feed Line 4 Inlets, 1 Air Sensor, 1 Pump A, 1 Flowmeter, 1 Pressure Post Pump A, 1 Pressure Post Pre-Filter, 1 pH/Cd Pre-Membrane, 1 Air Sensor Pre-Membrane, 1 UV Pre-Membrane, 1 Membrane w/ Bypass, 1 pH/Cd Post-Membrane, 1 pressure Post-Membrane, 1 UV Post-Membrane, 4 Fractions Order Number Capture CE Capture with Bubble Trap CE Capture with Bubble Trap UL Buffer Line 6 Inlets, 1 Air Sensor, 1 Pump B (Gradient/ILD), 1...

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Germany Sartorius Stedim Biotech GmbH August-Spindler-Strasse 11 37079 Goettingen Phone +49 551 308 0 USA Sartorius Stedim North America Inc. 565 Johnson Avenue Bohemia, NY 11716 Toll-Free +1 800 368 7178 or more information, visit F www.sartorius.com Specifications subject to change without notice. © 2022 Sartorius Stedim Biotech GmbH, August-Spindler-Strasse 11, 37079 Goettingen, Germany DIR: 2652012-000-00 | Status: November 2022

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Resolute® RCC MU
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