Ambr® Clone Selection Powered by Umetrics® Data Management Imported order CRITERIA FILTER Viability [%] (Last) Process Data Quality Data Clone Selection CLONE/VARIABLE PLOT Ambr® Clone Selection Powered by Umetrics® For Consistent Screening and Ranking Viability [%] (Last)

Ambr® Clone Selection Powered by Umetrics® Automated Screening and Ranking with Confidence Ambr® Clone Selection complements the experiments conducted with Ambr® systems. It simplifies the workflow for cell line screening and ranking. Users define selection criteria such as cell density, product titer and product quality attributes and assign priority weightings in order to screen and rank clones. The application uses a unique multivariable desirability assessment for clone ranking. Automation of the clone selection process improves speed and consistency Valuable scientist time is freed up leading...

Ambr® Clone Selection Automated Screening and Ranking Accelerating Research with Umetrics® Expertise Filter area Selection criteria are defined here as chosen values of key attributes The sliders are easily positioned to give an exact set of parameters which will provide the basis for the statistical analysis Ambr® Clone Selection Powered by Umetrics® Data Management Imported order CRITERIA FILTER Viability [%] (Last) Process Data Define objective. Should the variable be high - maximized low - minimized or meet a specific target? Ranking area A target proximity value is shown next to each clone...

Quality Data Clone Selection CLONE/VARIABLE PLOT Viability [%] (Last) Clone variable graph The maximum, minimum, last or integral values of the chosen variables are viewed alongside each other and can be compared to a similarity variable (reference), if used. Raw data graph Depiction of the raw data profile for selected variable and highlighted clone

Process and Quality Data Views Upload process and | or quality data for investigation. Timely resolved process data relates to measurements repeated several times during the process run. Quality data is gained from single time points measured during or after experiment completion. Raw data plot This shows all included clones and their process trend over time (x-axis) Ambr® Clone Selection Powered by Umetrics® VARIABLE DESCRIPTORS VCD [E5/mL] Last Data Management Process Data Quality Data IVCD Last Variable selection area List of all selected process variables. Check box to include variable in...

A multivariate similarity variable (such as a glycan profile) can be created and used for comparison as a reference. This feature allows you to calculate similarity of your chosen clone to a reference according to at least 5 selected variables. Target proximity (distance) represents similarity to the reference in relation to selected variables. The smaller the target proximity value, the more similar the clone is to the reference. IMO Clones and reference included As on process data view. Here the user can set a reference clone as indicated by the star to be used in the selection process Clone...

Reporting Function Select the candidate clones that you want in your report. A printable report (or save as pdf) from Ambr® Clone Selection software application will include: Ambr® Clone Selection Select filter profile Data Management Process Data Quality Data Clone Selection PROJECT REPORT NORMALISED DATA Summary plot of selected candidates and any references Table of selected candidates and any references A summary of the filter criteria used A project summary, listing the profile used, the names of the process and quality data files uploaded and number of candidates and variables used Viability...

Technical Specification The Ambr® Clone Selection application is a client-server software solution; which can be run on the same computer to allow clients local server access. For remote server access, clients must have direct network connection to the server installation/computer. Each license of the Ambr® Clone Selection software permits up to 10 concurrent users. Additional licenses can be purchased if required. Only a remote server installation can enable concurrent client usage the software application. If client and server are run on the same computer, only a single client can access the...

Single-Use from Cell Line Selection and Process Development to Production Scale Geometrical similarity of vessel design from Ambr® Clone Selection upwards Consistent mixing and gassing strategies Reliable single-use platform Perfusion | perfusion mimic capability Microcarrier and specialist mixing at low stirring speed capability Ambr® Clone Selection Data Management Imported order CRITERIA FILTER Viability [%] (Last) Process Data Quality Data Clone Selection CLONE/VARIABLE PLOT Viability [%] (Last) Ambr® Clone Selection Powered by Ulmetrics® Ambr® 15 Cell Culture Ambr® 250 High Throughput Clone...

Data Acquisition, Monitoring and Control of Bioprocesses Real-Time Multivariate Statistical Process Monitoring, Cultivation Monitoring Real-Time Release Testing Multivariate Data Analysis of Large Process Data Sets to Identify Key Trends, Correlations and Troubleshoot Scalable - scaling up from 0.025 L to 1000 L

Sales and Service Contacts For further contacts, visit sartorius.com Germany Sartorius Lab Instruments GmbH & Co. KG Otto-Brenner-Strasse 20 37079 Goettingen Phone +49 551 308 0 Specifications subject to change without notice. Copyright Sartorius Group. Version 2020 / 03