Ambr® Analysis Module pH Calibration and Raman Spectroscopy Integration

Ambr® Analysis Module Automates pH Calibration and Raman Spectroscopy for Ambr® Bioreactors The Ambr® Analysis Module is suitable for use with both cell culture and microbial media and supports two userselectable measurement modes for cell cultures up to at least 100 million cells/mL. It is not suitable for cultures containing particulates (beads or microcarriers, for example) or highly viscous samples. BioPAT Spectro in Ambr has been tested with CHO cell cultures but not microbial cultures. BioPAT® Spectro in Ambr® is suitable for use with mammalian fed-batch cell cultures but has not been evaluated...

Specifications Parameter Ambr® 250 High Throughput Sample volume, BioPAT® Spectro Cycle time per reading, pH Cycle time per reading, BioPAT® Spectro BioPAT® Spectro in Ambr® requirements Compatible Kaiser/Tornado Raman spectrometer and BioPAT® Spectro probe. Appropriatre SIMCA® license (not included). Win10

BioPAT® Spectro in Ambr® Enables Integration of Raman Spectroscopy BioPAT® Spectro in Ambr® enables the automated integration of Raman spectrometers from Kaiser Optical Systems and Tornado Spectral systems, via a Sartoriusspecific fiber optical probe. BioPAT® Spectro in Ambr® Benefits Automated consolidation and contextualization of all spectral and process data into a SIMCA®-ready file for model building Ambr® derived Raman models are more robust due to the use of all process data, a large DoE design space, and automated spiking of Ambr® samples with analyte stock solutions Ambr® can use SIMCA®...

A. Glucose measurement using Raman Prediciton vs integrated FLEX2 9 8 FLEX2 Reference Raman Control A. Glucose measurement using Raman Prediciton vs integrated FLEX2 B. Glucose control using Raman Prediction vs integrated FLEX2 FLEX2 Control FLEX2 Reference Raman Control B. Glucose control using Raman Prediction vs integrated FLEX2 Raman Control

BioPAT® Spectro Platform Meeting the Needs of Process Development and Commercial Manufacturing Ambr® 15 Cell Culture Ambr® Analysis Module Ambr® Analysis Module Ambr® computer Raman spectrometer and controller Optical probe BioPAT® Spectro in Ambr® Find out more https://www.sartorius.com/en/products/process-controldata-analytics/process-analyzers/biopat-spectro Raman spectros

Biostat STR® Ambr® 250 High Throughput Ambr® 250 High Throughput Ambr® computer Raman spectrometer and controller Spectrometer control software Raman Spectrometer Liquid circulates through BioPAT® Spectro single-use port BioPAT® Spectro in Biostat S

Consumables Operation of the Ambr® Analysis Module is supported by replaceable sensors, a replaceable BioPAT® Spectro flow cell, and reagent kits including calibration solutions, cleaning solutions and a waste container. The ability to reliably measure pH is process, cell line, and cell density dependent. It is recommended pH and Reference sensors be replaced at least every 3 months. Actual lifetime will be dependent on process application and may necessitate more frequent replacement. BioPAT® Spectro flow cell for Ambr® Analysis Module Germany Sartorius Stedim Biotech GmbH August-Spindler-Strasse...