8RRA12-04_Autopol4_TB909v2.qxd:Layout 1 12/12/12 4:25 PM Page 2 For research, analysis and control ® The Autopol IV Automatic Polarimeter United States Department of Commerce National Institute of Standards and Technology Including Autopol Model Selection Guide NVLAP LAB CODE: 200898-0 Accreditation to ISO/IEC 17025:2005 The brand of polarimeter used in more labs than any other.* TECHNICAL BULLETIN 909 *Emmes Surveys

A sensitive nondestructive technique for measuring the optical activity exhibited by inorganic and organic compounds. A compound is considered to be optically active if linearly polarized light is rotated when passing through it. The amount of optical rotation is determined by the molecular structure and concentration of chiral molecules in the substance. Each optically active substance has its own specific rotation as defined in Biot's law: The polarimetric method is a simple and accurate means for determination and investigation of structure in macro, semi-micro and micro analysis of expensive...

Measurement Modes The Autopol IV can read directly in one of four measurement modes: Optical Rotation, Specific Rotation, Concentration or Specific Rotation Plus. Specific Rotation Plus allows a correction to be applied to a result for loss on drying. Each measurement mode can be activated via touchscreen selection. Sample cells Concentration is entered as a percentage. Temperature Control is allowed through rubber gasketing in the Autopol door which permits tubing to be connected from an external temperature controlled Water Bath to the jacket of a jacketed polarimeter sample tube. (See WATER...

8RRA12-04_Autopol4_TB909v2.qxd:Layout 1 12/12/12 4:25 PM Page 5 Choosing a Polarimeter That’s right for your application and budget Autopol I Autopol III The accuracy of our entry-level model is ± 0.02 Degrees Optical Rotation. This accuracy is fine for food and educational applications where budget is critical but state of the art quality is still important. The Autopol I is not a pharmaceutical grade polarimeter and does not come with IQOQ (Installation Quality Operation Quality) documentation. Rudolph’s entry-level pharmaceutical and research grade polarimeter has ± 0.002 Degrees Optical Rotation...

8RRA12-04_Autopol4_TB909v2.qxd:Layout 1 12/12/12 4:26 PM Page 6 Autopol IV Autopol V Plus This model is available in one, two and six wavelength versions and has a more expensive optical system than the Autopol III. It is the system of choice for research universities, pharmaceutical and fine chemical research departments. This instrument is also excellent for studying racemics and kinetics. Temperature control may be accomplished through a circulating Water Bath or with Rudolph’s optional Patented TempTrol™ System, which electronically heats and cools the sample to a specified temperature without...

Measuring Mode Measuring Scale Optical Rotation, Specific Rotation, Concentration, Degrees Arc Optical Rotation Optical Rotation, Specific Rotation, Concentration, Degrees Arc Optical Rotation Optical Rotation, Specific Rotation, Concentration, Sugar Degrees, °Z (ISS) Degrees Arc Optical Rotation 0.01 ° Arc Optical Rotation, 0.01 % Concentration 0.01 ° Arc Optical Rotation, 0.01 % Concentration Concentration, 0.001 Specific Rotation 0.01 ° Arc Optical Rotation, 0.05°Z (ISS) Sugar Degrees 0.01 ° Arc Optical Rotation, 0.03°Z (ISS) Sugar Degrees Resolution: 0.001 ° Arc Optical Rotation Reproducibility:...

Rudolph Research Analytical 55 Newburgh Road, Hackettstown, NJ 07840 USA ■ Phone: 973-584-1558 ■ Fax: 973-584-5440 ■ E-mail: [email protected] ■ Internet: www.rudolphresearch.com

8RRA12-04_Autopol4_TB909v2.qxd:Layout 1 12/12/12 4:25 PM Page 1 Full cGMP/GLP Compliance Quality cGMP/GLP Printing No matter which model Autopol you choose, Rudolph uses the same high quality optics. While other manufacturers use Polaroid Plastic Dichroic Sheet Polarizers, Rudolph does not. Instead, Rudolph uses the same high quality Glan Thompson Calcite Polarizers in all its models. Measurement reports can be saved as an Excel or PDF file and edited quickly and easily. You can import logos and print your company’s customized “C of A” directly. Why are high quality polarizing prisms important?...