CPC MODELER Laboratory-Scale Method Development CPC Platform

From Laboratory to Production With a Single Technology A Single Handshake For Long-Term Success Producing APIs, and natural extracts, or purifying legally challenging compounds doesn’t just happen by purchasing a purification device and then going into production. Research and development (R&D) and scale-out often provide difficulties and challenges for manufacturers. ins and outs of a single technology just to leave it behind in the next stage, and then keep learning new techniques every step of the scale-out process going into production. Companies often must purchase a variety for devices,...

Chromatography Across the Purification Landscape Chromatographic methods can be categorized into analytical and preparative, depending on the scale and purpose of the separation process. Analytical methods are designed to provide qualitative and quantitative insights into the sample at hand. On the other hand, preparative separations aim to separate, isolate or remediate the compound of interest (CoI) from a mixture. These preparative systems can handle large input quantities, processing hundreds or even thousands of grams. Devices for Preparative Chromatographic Purification Chromatographic...

Flash chromatography uses air pressure, or a pump in place of gas to move solvent through a column filled with a solid. Flash chromatography is typically used for medium-scale preparative purification, providing moderate throughput and allowing for * the separation of larger quantities of compounds quickly. CPC surpasses flash with many of its characteristic advantages: ' Higher Sample Loading: CPC efficiently handles larger volumes for purifying greater quantities of compounds. ' Reduced Solvent Consumption: CPC uses less solvent, reducing waste and operating costs, particularly in large-scale...

RotaChrom's CPC technology offers an easy scale-up and scale-out solution to the partners. Our product portfolio covers solutions for purification, method development, pilot-scale research, continuous production and industrial-scale separation, isolation and remediation. RotaChrom instruments are available as both standalone instruments, and as part of purification platforms. Our proprietary automated biphasic solvent system handles solvent usage, capable of solvent preparation and recovery and regeneration. All our devices can be constructed according to cGMP compliant standards on-demand. CPC...

ROTACHROM CPC MODELER iCPC: Industrial-Scale CPC Purification The iCPC is the largest serialized CPC instrument in the world, designed for industrial-scale purification projects. This device is by far the most cost-effective industrial-scale chromatography platform available on the market. With its kg/cycle loading capacity, it has the capacity to process up to tens of kg of crude input material per day. The iCPC, also a core element of the pCPC platform, always comes with solvent preparation and recovery and regeneration systems. Rotor volume Nominal Flow Rate Loading Capacity Typical Run Time...

CPC Modeler Make Your Downstream Journey Easy With CPC The CPC Modeler is a quick and robust method development platform. It seamlessly integrates an intuitive method development engine with tailor-made semi-preparative chromatographic equipment. The CPC Modeler not only tests, predicts and validates optimal purification methods for various Compounds of Interest (CoI) but also facilitates seamless production scalability. The Modeler is the first platform in RotaChrom’s ecosystem. Scale-out can be made extremely easy, as the technology offers a solution for every step of the downstream process....

Benchtop CPC The Benchtop CPC is RotaChrom’s laboratory-scale centrifugal partition chromatography device. It is an integral part of the CPC Modeler platform, and as such, this is the device which carries out the chromatographic separations. The device is based on RotaChrom’s CPC technology, with a customized rotor design outfitted with liquid delivery and detection devices and a fraction collector. As its name suggests, the device can fit on top of a standard desk, making it ideal for laboratory-scale method development tasks. The Benchtop CPC offers mg to grams scale/cycle loading capacity,...

CPC Simulator A Tool For Proposing the Optimal CPC Method Achieving optimal resolution is paramount in developing a purification method. The CPC Simulator tool, as the part of the CPC Modeler, and as an individual tool, lets you find the most effective CPC purification method and evaluate the productivity of your compound of interest. The simulator lets you select between predefined instruments and separation modes. Several important factors affecting peak shape and separation performance are considered in the model calculations to improve the simulator’s predictivity. These include high concentration,...

The CPC Visualizer is a predictive tool developed by RotaChrom, which can help you predict and visualize the CPC elution profile of a crude material without lab equipment. Using the built-in separation scenarios and predefined instrument settings the application can be used to get a better understanding of the concepts of the examined CPC separation. After inputting the composition of a crude material and the partition coefficients in a selected solvent system, the application helps you predict if the planned CPC separation will be successful or not without using any laboratory equipment. Instrument...

[email protected] www.rotachrom.com RotaChrom delivers innovative, sustainable and efficient chromatography to produce a variety of compounds for use in many different industries. Csillag street 2/A, Kecskemet, HU-6000 RotaChrom North America Inc. 300 Spectrum Center Drive, Irvine, CA 92618, USA +1 720 220 5669 RotaChrom® is a registered trademark of Rotachrom Technologies in the USA and EU. All rights reserved. RotaChrom Technologies LLC (Headquarters)