When & How to Use a Powder Vibrator FOR PROFILLER 1000, 3000, AND VCF SERIES A. RECOMMENDED TIME & TIPS We recommend a vibration time of 30-60 seconds for most powders. Longer vibration times do not result in higher fill weights for most powders other than fluid-like powders. While vibrating we recommend spreading the powder across the capsule bodies to reduce fill weight variation. Remember to spread powder to all four edges of the filling surface. For many powders (including fluid-like, fine and fluffy powders) you can achieve a higher fill weight with a combination of vibration, spreading and tamping. Vibrate and spread the powder for 30-60 seconds. Use a Tamper to press powder gently into the capsule bodies without forcing powder out of the capsule bodies. Repeat vibration and spreading followed by tamping. After the final tamping, spread any remaining powder across the capsule bodies. For maximum fill weights, you can do up to 4 vibration/spreading and tamping cycles. In general, we do not recommend more than 2-3 cycles as we have found that with all powders we have tested, the fill weight does not increase by more than 1-2% after 3 cycles. Due to wide variations in properties between powders, their grades and suppliers, your results will vary. B. BENEFITS OF POWDER VIBRATION • Reduced Filling Time - 60 seconds or more per cycle • Increased Fill Weight • Reduced Fill Weight Variation You may see some or all of the above benefits depending on the properties of the powder filled. A Vibrator is also helpful when filling 2 or more tablets inside capsules. Tablets can fall and sit vertically inside the capsule body, leaving insufficient room for more tablets. Powder Type Examples (Common Excipients in Bold) Some powders form a bridge at the top of the capsule body, leaving air pockets inside the capsule body. The capsule appears full but it is not. A Vibrator breaks up powder bridges and eliminates air pockets resulting in a reduced filling time and reduced weight variation. Avicel PH105, Calcium Carbonate, Ginseng, D-Glucosamine Sulfate 2 KCL, Lactose Fine Powder, Mannitol Fine Powder, Metoprolol Succinate, Peanut Powder, Respitose ML001 & ML006, Talcum, Tyrosine Similar to bridging powders but also stick to surfaces. As the powder bridges during the first spreading only a small portion of powder enters capsules and most remains on the Filler surface. During the first tamping, the Tamper pins enter deep into the capsules and the powder on the Filler surface sticks to the bottom surface of the Tamper plate. Vibration settles more powder into the capsules and eliminates this effect. Diatomaceous earth, Dolomite, Frankincense, Griseofulvin, Lactose Fine Powder, Metoprolol Succinate, Peanut powder, Starch, Talcum Fluid-like, Fine or Fluffy Do not settle quickly and are pushed out of the capsule bodies as the Tamper pins enter. For powders requiring more than 2 or 3 tamping cycles because of these effects, a powder vibrator is very useful. Aluminum Hydroxide, Charcoal, Ginseng, Milk Thistle P.E. Min 80% Silymarin Tamping can damage granules or pellets. A powder Vibrator eliminates the need for tamping these powders. Creatine Monohydrate, Omeprazole ProTip When & How to Use a Powder Vibrator 1911

Another method of classifying powder is using Hausner’s Ratio and the Angle of Repose. Based on trials in our labs, we make the following recommendations. Hausner’s Ratio Angle of Repose Results when using Vibration >1.35 >40° ExCellent Due to wide variations in properties between >135 >350 Good powders, their grades and suppliers, your results C. POWDER VIBRATION TECHNIQUE View our online videos at www.profiller.com/vibrators We recommend a combination of vibration with spreading, tamping/tapping, and spreading as follows. Tapping refers only to the 1000 series and 3600 hand-held models. Capsules...