NUCLEOTM BIOREACTORS TITRE SINGLE - USE 20L TO 1,000L W/V Innovative Solutions and Support TOGETHER BRING LIFE TO YOUR PROJECTS 1

NUCLEOTM BIOREACTORS FOR BIOPROCESS SCALE UP AND PRODUCTION RUNS EXPERIENCE & INNOVATION Utilizing its expertise in industrial bioprocesses and automated systems, PIERRE GUERIN - BIOLAFITTE offers its NUCLEOTM series, a new generation single-use bioreactors designed for optimization studies, scale-up and production runs in GLP or GMP environments. These systems represent the best pre-engineered cell culture devices and are suitable for the cultivation of either suspended or attached cells, in batch, fed-batch or perfusion mode (with appropriate accessories) . MAMMALIAN CELL CULTURE VIRUS AMPLIFICATION...

□ Single-use vessel in TK8 bioprocess film (multi-layer film with contact layer in ULDPE, gamma sterilisable, USP - Class VI compliant, fully ADCF (Animal Derived Component Free)) □ Available working sizes : 20, 40, 100, 200, 500, 1,000 L agitation □ Central agitation incorporating a mixing paddle coupled with a dynamic sparger □ Corners of the cube-shaped design acting as baffles □ High oxygen and thermal transfer performances for minimum shear force ^CCessORie? □ 6 x Product lines for inoculation, media loading and sterile reagents additions □ 3 to 6 x Ports for probes and sensors □ 2 x Connexions...

NEPTUNE CONTROL SYSTEM Hardware configuration □Micro-PLC / PC based control with a wide choice of Human Machine Interfaces: laptop or desktop PC as standard or optional Industrial Touch Screen Panel □ Up to 32 configurable control loops for a wide range of process parameters including temperature, pH, Redox, speed control, pO2, foam, gas flow rates, weight or level, OD, pO2 / pCO on gas exhaust □ Control types include : PID, digital on/off and others - cascade mode for advanced control strategies NEPTUNE TM InTouch includes the following modules □ Customized User Access module complying with...