BIOCELLTM Lab & Pilot Series STEAM IN PLACE BIOREACTORS 10L to 300L W/V Innovative solutions and support BioCell Bioreactors Scale-up and production GMP applications PG’s fermentation solution: Affordable modularity

BIOCELLTM BIOREACTORS FOR BIOPROCESS SCALE UP AND PRODUCTION RUNS Experience & innovation Utilizing its expertise in industrial bioprocesses and automated systems, PIERRE GUERIN - BIOLAFITTE offers its BIOCELLTM series, a new generation of Lab & Pilot Steam In Place bioreactors designed for optimization studies scale-up and production runs in GLP or GMP environments. These systems represent the best pre-engineered cell culture devices and are suitable for the cultivation of either suspended or attached cells in batch, fed-batch or perfusion mode (with appropriate accessories). MAMMALIAN CELL...

BIOCELL™ BIOREACTORS Vessel, agitation & accessories Vessel Jacketed vessel fitted with removable head plate Available sizes : 10, 20, 30, 60, 100, 150, 200, 300 w/v -working aspect ratio of 1:1 Material (product-contact parts): stainless steel grade 1.4404 (316L) Finish (product-contact parts): Ra < 0.5 pm for vessel (with electro-polishing) and piping Maximum operating pressure: 3 bar g for vessel and jacket Agitation Bottom or top mounted agitation equipped with one HTPG4™ impeller or equivalent like pitched blade or marine impeller - tip speed : 2 m/s Agitation with magnetic coupling Round...

BIOCELL™ BIOREACTORS Instrumentation Automatic control of temperature, speed of agitator, pH and pO2 O2 flow rate to the sparger automatically controlled by mass flow meter and air / CO2 flow rate to the head space controlled via rotameters and automatic valves NEPTUNE InTouch Advanced version (additional modules to the standard software version) Strategy module enabling process to be defined stepwise for process customization and repeatability typically used for feed control, complex gassing addition, set-points ramps or event based actions Code Instrumentation 40 Air mass flow controller in...