PTG-S5 Automated Powder Flow Analyzer The PTG-S5 automated powder flow analyzer is used to measure the flow behavior of granules and powders in compliance with the EP <2.9.36>, EP <2.9.16>, USP <1174> Pharmacopoeia and ISO 4324 standards. This instrument determines the powder flow time, the powder cone angle of the collected powder mound, the weight, the density and the volume of the powder cone. Furthermore, the EP "flowability" result is calculated by measuring the flow time of 100g of sample through a specified pouring nozzle. The PTG-S5 is equipped with a clear view dust hood, made from anti-static material, to protect the user from most of the dust during the powder analysis. This hood can easily be opened or removed completely for cleaning. The instrument is operated using a large color touch screen. Pharma Test Apparatebau AG Siemensstr. 5 63512 HAINBURG GERMANY T: +49 6182 9532-600 F: +49 6182 9532-650 [email protected] www.pharma-test.com THE PHARMA TEST GROUP

PTG-S5 - Automated Powder Flow Analyzer Why Measure the Flow Properties of Powders? It has been estimated that over 50% of the materials used in all industrial applications were at some stage in a powder form. These powders need to be transported, injected, propelled and be able to pass through various process stages before they achieve their final form. This final form may be a tablet, a suspension or indeed a powder formulation. The need to be able to measure, control or test for reproducible powder flow has been well established in many industrial applications. Powder flow characteristics...

PTG-S5 - Automated Powder Flow Analyzer In processes, which rely on powder and / or powder, mix integrity, the need to have the correct powder flow characteristics is paramount. These powder mixes have to be formulated, mixed and certainly transported. Transportation, even over small distances an easily lead to classification of sorts such that “fines” may drop out and alter the particle size distribution and hence the flow characteristics. For example, we can look at formulated mixtures, which are fed into tableting machines: these powders need to flow in exactly the same way from batch to batch....

PTG-S5 - Automated Powder Flow Analyzer Operating Principle of the PTG-S5 The PTG-S5 is widely used to compare batches of powders perhaps supplied by the same manufacturer over a period of time or for similar materials provides by different suppliers. The flow characteristics can be easily and quickly determined as a QC tool for inter- batch reproducibility, as this may have a distinct bearing on the ease of production especially if powders are capable of agglomeration and cohesion over time. The design is compliant to the ISO 4324 (12/83) standard, EP <2.9.36>, and USP <1174>. A conical funnel,...

PTG-S5 - Automated Powder Flow Analyzer A test report and powder flow-chart will be printed including descriptive information of the product. The report is printed either via the built-in thermal printer or using any Microsoft Windows compatible printer connected directly to the instrument by USB or through a network. To measure the flowability as per EP <2.9.16> and USP <1174> Pharmacopoeia the test is automatically stopped as soon as 100g of sample have been collected inside a plastic beaker. In addition to the flowability factor (100g/t) the powder flow chart can be printed. The standard instrument...

PTG-S5 - Automated Powder Flow Analyzer User Interface PTG-S5 includes a sophisticated user interface using a large integrated color touch screen. Log on to the instrument by selecting your user from the list and by entering your password. You can either use the on screen keyboard or you can connect any standard USB keyboard to the instrument to enter your data. Depending on your access level, you can log on with different authorization levels. This access authorisation level determines which menus displayed and which settings can be changed. This is the method definition menu. You can enter...

PTG-S5 - Automated Powder Flow Analyzer The test results are displayed on screen and can be recalled at any time from the integrated result database. The results are expressed numerically and graphically. Furthermore the flow behaviour is evaluated according to the USP/EP criteria. You can create additional users directly on the instrument and assign authorisation levels to them. For each user you can see when he was created or modified and by whom. You can also see when last logged in and any failed login attempts as well. It is possible to automatically lock a user account after a certain number...

PTG-S5 - Automated Powder Flow Analyzer A detailed audit trail shows any event in the application. This can be filtered by date. The instrument also features a service menu that allows to test the components and sensors of the system. You can check the interal system temperature, power consuption of major components and the inclination of the instrument using an integrated sensor. Testing Smaller Volumes For smaller volumes, a 10ml funnel and a smaller sample-collecting dish are available. This optional accessory can be used with pouring nozzles from 4 to 10mm diameter. A suitable stirring shaft...

PTG-S5 - Automated Powder Flow Analyzer PTG-NIR Option The PTG-NIR automatic powder and granule analysis system combines the Pharma Test PTG-S5 powder flow testing instrument with an integrated J&M TIDAS L NIR diode array spectrometer. The system is controlled by the powerful TIDASDAQ3 software including a customized script for the PTGNIR. The system is ideal to examine the flow characteristics of a powder or granule. This combination is ideal for simultaneous detection of chemical, physical and morphological information. This information is describing the flow behaviors of a powder or granule....

PTG-S5 - Automated Powder Flow Analyzer Reduce process costs Improve product consistency from batch to batch Keep tight control of component powders, especially if they are natural products Compare sources of powdered products Provides an easy method to achieve quality control on bulk incoming component products Provides an easy method for the control of dry and wet mixing, tableting, granulating, and capsule filling Predict powder transport through conveyors, air lifts and in silos Predict powder suitability for capsule and bottle filling Predict product settling during transport, so called...