ADS-L 820 Fully Automated Tablet Dissolution Testing System The online dissolution system ADS-L 820 consists of a Pharma Test dissolution tester PTWS 820D, the DAD UV/VIS spectrophotometer TIDAS L and a multichannel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components. The PTWS 820D The PTWS 820D is an 8 position 4-by-2 or 2-by-4 dissolution bath with an automated lift system for the instrument head. An automated sampling manifold EPE is used to perform dissolution tests as per USP Apparatus 1, 2, 5 and 6. Each 316 stainless steel tube which is part of the EPE sampling system can be equipped with in-line filters to avoid the transfer of undissolved particles into the measurement cells of the spectrometer. The tablet magazine includes magnetic holders for the tube cleaning device. Pharma Test Apparatebau AG Siemensstr. 5 63512 HAINBURG GERMANY T: +49 6182 9532-600 F: +49 6182 9532-650 [email protected] www.pharma-test.com THE PHARMA TEST GROUP

ADS-L 820 – Fully Automated Tablet Dissolution Testing System The TIDAS L DAD Spectrometer with Cuvette Changer J&M’s latest models of laboratory spectrometers, the TIDAS L series of diode-array spectrometers, follow an approach of integration. The diode array technology gives you rapid results over the full spectrum with each measurement. It feature an integrated Windows based PC with a large, highresolution touch screen running the WinDiss ARGUS and the additional spectrometer software TIDAS DAQ 3. By integrating the PC into the spectrometer unit the TIDAS L instruments make excellent use of...

ADS-L 820 – Fully Automated Tablet Dissolution Testing System The Multichannel peristaltic pump The IPC Pump is a very well-known multichannel pump which is suitable for online dissolution measurements. It is used to transfer the dissolution media in closed loop from the vessel to the spectrometer and back to the vessel. WinDiss ARGUS Software WinDiss ARGUS is a revolutionary scientific dissolution data management software tool for instrument control and advanced data acquisition, management, processing and reporting – designed by users for users. Whether you perform dissolution tests occasionally...

ADS-L 820 – Fully Automated Tablet Dissolution Testing System Principle Online Dissolution Testing System The multi-channel IPC pump is used to transfer the media from the vessels to the spectrometer. The samples here are circulated in a closed loop, so that there is no sample volume loss over the time of the dissolution test. At the programmed time point the sample circulation is stopped and either a single point absorbance reading or a full UV/VIS spectrum of each vessel is collected. The control of the entire system as well as the data handling, calculation and reporting is performed by the...

ADS-L 820 – Fully Automated Tablet Dissolution Testing System Automation for optimization of laboratory processes Offers unattended operation after start of dissolution run Full spectral data in milliseconds Multicomponent analysis with the TIDAS L 570 DAD UV/VIS spectrometer Very short sampling time-intervals with the full spectral information No media loss due to closed loop design Pharma Test takes full system responsibility Hardware IQ/OQ documents included free of charge Automated temperature check and log at all sampling times Sampling, measuring, and result calculation are automated Online,...

ADS-L 820 – Fully Automated Tablet Dissolution Testing System Standard Scope of Supply The ADS-L 820 comes ready to use with the following standard scope of supply: » TM-820 manual tablet drop magazine » EPE-820 automated sampling system » Cleaning system for tubing lines with magnetic holders » One set of stainless steel paddles » One set of batch coded 1000ml Borosilicate glass vessels » One set of depth adjustment balls » One bottle of ALGEX water preservative » The TIDAS L 570 DAD UV/VIS Spectrometer » Cuvette changer with 8 positions + 3 additional ports for fiber optic probes » Integrated...

ADS-L 820 – Fully Automated Tablet Dissolution Testing System Options In addition to the standard scope of supply Pharma Test offers a broad range of accessories and options including: » » » » » » » » » ITM-820 individual media temperature monitoring system TMA-820 motorized tablet drop magazine PT-RP80 serial report printer 2 liter vessel version (can also be used with 1 liter vessels) 250 ml Mini Vessel set incl. mini paddle stirrers Amber colored vessels for UV sensitive test materials Full range of MonoShaft™ stirring tools available Full range of certified validation tools available Different...

ADS-L 820 – Fully Automated Tablet Dissolution Testing System Technical Specifications ADS-L 820 Parameter Dissolution Bath Spectrometer Spectrometer Specifications Pump Tubing Software PC Tubing Installation Sampling System System Dimensions Packaging Dimensions Net / Gross Weight Certification CE / EMC Certification Validation Specification PTWS 820D 8-position dissolution bath TIDAS L UV/VIS diode-array spectrometer with 8 channel cell changer, 3 additional channels for fiber optic measurements Wavelength Range 190 – 1100 nm (Spectral resolution ≤ 2 nm); Included light source: 35 W Deuterium/...