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Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography

Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography

Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography

Product catalog summary
Abstract: Helium has been a traditional choice as a carrier gas in gas chromatography since the mid-20th century. However, its high cost and fluctuating supply due to dependency on natural gas production make it less favorable. Nitrogen, in contrast, is cost-effective, abundant, and can be generated in-house, enhancing lab efficiency and sensitivity in flame ionization detectors (FID).
Introduction: The carrier gas in gas chromatography must be inert. Helium, though traditionally used, is rare and expensive due to its limited availability and strategic importance. The U.S. government controls its sale, and prices have been rising.
A Shift toward Nitrogen: Nitrogen is a viable alternative to helium, being nonreactive and abundant. It can be generated in-house, eliminating the need for heavy tanks and reducing costs significantly. The initial investment in a nitrogen generator is quickly recouped, and ongoing costs are minimal.
In-House Nitrogen Generation Process: The process involves several stages, including pre-filtration, adsorption of volatile compounds, particulate filtration, hydrocarbon removal, cooling, and nitrogen purification via a semi-permeable membrane. This results in high-purity nitrogen and zero air for FID support.
Advantages of In-House Gas Generation: Key benefits include safety, convenience, cost savings, reduced environmental impact, and elimination of contamination risks. The system is hard-plumbed, providing a constant supply of nitrogen without the risks associated with tank handling.
Becoming Lean: In-house nitrogen generation aligns with lean principles by simplifying processes, reducing costs, and increasing efficiency. It eliminates unnecessary steps associated with helium use, such as tank monitoring and handling, thus enhancing competitiveness.
Conclusion: The shift from helium to nitrogen for gas chromatography is driven by cost and efficiency benefits. In-house nitrogen generation offers significant advantages, including lower costs, increased productivity, and enhanced operational control, making it a superior choice for laboratories.
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Catalog excerpts

Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography-1

Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography aerospace climate control electromechanical filtration fluid & gas handling hydraulics pneumatics process control sealing & shielding

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Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography-2

Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography Peter Froelich, President Peak Media, Franklin, MA Abstract Helium has been used as a makeup or carrier gas in the gas chromatography process since the 1950s-1960s. However, there are several major disadvantages to helium: it is expensive and the supply can fluctuate, depending on natural gas production and national supply-and-demand factors. Helium is also only available in tanks. Nitrogen, on the other hand, performs just as well as helium as a carrier gas and is far less expensive. The supply of nitrogen gas is unlimited and...

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Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography-3

Gas Separation Membrane Permeate Outer side dense Fiber wall porous Pressurized air Inner side open te Figure 2: Separation of nitrogen via a semi-permeable membrane. poison the catalyst. If halogenated hydrocarbons are present in the compressed air at a level exceeding 5 ppm, an auxiliary activated carbon scrubber can be used to avoid poisoning the catalyst. 3. Particulate filtration. A BQ-grade filter (99.99-percent efficient at 0.01 µ) is placed after the activated carbon filter to ensure that activated carbon particles are removed from the stream. 4. Hydrocarbon removal. A cartridge heater...

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Nitrogen: The Most Cost-Effective Makeup Gas for Gas Chromatography-4

5. Elimination of contamination. An in-house nitrogen generator eliminates the possibility of introducing foreign materials when a new tank is installed. When a tank is used to provide nitrogen, the user must periodically break the connection between the supply and the detector to install a new tank, which could lead to the introduction of materials from the atmosphere that would have a negative impact on the FID measurement. Becoming Lean There is no question that in-house nitrogen gas generation saves money after the initial investment is recovered, typically within about one year. What is...

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