HPLC-xf Systems Prep and Load Platform Front-End Automation for LC / LC-MS Systems and Options High Throughput Screening Environmental, Food Safety, Forensics Preclinical Research, Metabolomics Drug Metabolism, Pharmacokinetics Protein Biomarker Discovery

PAL is a registered trademark of CTC Analytics AG | Switzerland

fY\ L SYSTEM Prep and Load Platform Content PAL-xt Dimensions and Option chart 2 - 3 PAL HTC-xt 4 - 5 PAL HTS-xt 6 - 7 PAL HTX-xt 8 PAL Diluter Option 9 PAL X-Type Syringe 9 PAL DLW Option 10 - 11 PAL Maldi Option 12 - 13 PAL Valve Options 14 - 15 Cycle Composer 16 General Specifications 17 To learn more about the unique PAL Series of LC/LC-MS sample handling systems or any of our GC/GC-MS sample injection systems contact your PAL System distributor. 1

PAL HTS-xt equipped with Stacks for 12 standard and for 6 deepwell microplates HPLC System-xt Prep and Load Platform PAL HPLC System-xt Open and modular architecture Fast cycles and near zero carryover due to DLW option Precise and Accurate sample Loading for high throughput environment, flexible analysis requirements and limited bench space situations New design Various accessories and options available To meet the demand for increased sample throughput and flexibility CTC introduces the PAL HPLC-xt product Line. Built on the successful PAL product line, the new PAL HPLC-xt offers faster speed...

PAL HTC-xt PAL HTS-xt PAL HTX-xt Dimensions Width: 534mm Depth: 385mm Height: 648mm Width: 828mm Depth: 385mm Height: 648mm Width: 1206mm Depth: 385mm Height: 648mm Injection Valves 1 up to 2 up to 2 Additional Switching Valves up to 3 up to 6 up to 9 4 -fold Injection Valve Drive no yes yes 0.15mm Nano Injection Valve yes yes yes 1200 bar UPLC Valve yes yes yes Column Selector Valve no yes yes PAL Dilutor Option no yes yes PAL Active Washstation yes yes yes PAL DLW Option yes yes yes PAL MALDI Spotter / Fraction Collection yes yes yes Injection Volume 0.1(aI - 5000^x1 0.1(jJ - 5000^x1 0.1(aI...

PAL HTC-xt equipped with 1 Stack Cooler and Active washstation Prep and Load Platform Entry-Level model in 50 cm length Variable instrument setups in a compact size Open architecture for easy access to samples, valve and syringe Software control by all leading LC-MS Systems PAL HTC-xt Entry-Level System The PAL HTC-xt offers the smallest footprints in the industry standard range of PAL-xt Autosamplers but still provides major sample capacity. Load up to 12 deepwell microplates, 24 standard microplates or 648 2ml vials or even mix up the loads to meet your workload. The PAL HTC-xt provides outstanding...

Prep and Load Platform PAL HTS-xt High Throughput System The PAL HTS-xt is designed to meet requirements in terms of speed, capacity and High-Throughput model in 80cm length precision in chromatography Front End automation. The PAL HTS-xt is the ideal platform for high throughput applications. 4-valve operation for parallel or staggered sample analysis Besides 96/384 standard or deepwell microplates the PAL HTS-xt injects samples out 2- or 3-valve operation for multidimensional of 1ml/2ml/10ml/20ml vials or various types of test tubes directly into the LC valve. chromatography Upgradable with...

Prep and Load Platform PAL HTX-xt Ultra High Throughput System The PAL HTX-xt fits into the high throughput analysis market where large numbers of Extended X-axis length of 120cm samples have to be characterized in a short period of time. Injection onto FIA/MS, parallel HPLC or MUX Systems The HTX-xt version has an extended X-axis allowing up to 4 PAL Stack6DW or 4 PAL StkCoolers to be easily installed. Compatible with all major LC/LC-MS Systems the PAL Built for unattended 24 hour/day Mass Spec analysis HTX-xt has all the flexibility you would expect from a PAL System. Various accessories and...

Adding the Dilutor to a PAL extends it's sample prep capabilities. It can be used to dispense liquid prior sample injection and combines the "add liquid" and "inject" steps without user intervention or syringe change. Typical applications are dilutions, derivatisations, sample spiking or standard additions. Dilutor syringes up to 10ml ensure large dilution ratios. Another important Dilutor application concerns the injection valve and syringe wash procedure in LC- MS high throughput systems. Replacing the standard Fast Wash Station, the Dilutor can be used to clean the injection syringe as well...

Prep and Load Platform Near Zero Carryover - Fast Cycles and exceptional reproducibility Clean and efficient removal of carryover in the entire flow path Holding loop for effective rinsing of the complete sample path Integrated pumps for active wash solvent delivery Selectable wash time for organic and aqueous solvents Spring loaded syringe needle positioning in needle guide - no dead volume Existing PAL Systems can be upgraded X-Type Syringe based Today's Mass Spectrometers are so sensitive that carryover becomes an issue again. To meet today's requirements for fast, clean and reproducible LC-MS...

Dynamic load and Wash Cycle principle Syringe minutes 0 Old Syringe I I I 4 minutes 67 seconds 51 seconds I I I I I I I I I DLW Standard Fast DLW Wash Solvent 1 Wash Solvent 2 Pump 1 c=> Pump 2 cz> > 2 Solenoid / ^ Actuator Valve i i i Cycle speed comparison Holding Loop Rear air gap Wash Station Sample Sample Loop Front air gap Download pdf Standard Cycle Fast Cycle Stator Wash Cycle www.palsystem.com Waste Pump Wash Station Syringe Specifications DLW Option Solenoid / Actuator Valve - Pump & m Solvent 1 v- ՗ Wetted parts material: Syringe Size: Stainless steel, PEEK 100[xl Reproducibility (partial...

Maldi Option PAL HTS-xt equipped with Maldi Option, Stacks for standard and deepwell microplates Prep and Load Platform On-line Fraction Collection onto MALDI Targets or microplates ... , ■ , , , -,r Rapid and accurate identification and quantification of proteins is one of the goals of tona capillary and mcrotore LC ^^ci with fraction todays proteomics research. One key requirement for this approach is the ability to collection onto MALDI targets or microplates resolve the individual components of peptide mixtures prior to MS analysis. The challenge is to achieve high sensitivity with limited...