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The Only Full-Capability AFM on an Inverted Optical Microscope Atomic Force Microscope

Uncompromised AFM on an Inverted Optical Platform The MFP-3D-BIO provides the highest sensitivity and most accurate images and measurements possible on an inverted optical platform. The NPS™ closed loop nanopositioning sensors on all three axes ensure distortion-free images on samples as small as proteins and as large as cells – in both air and liquid. The MFP-3D measures the cantilever deflection to better than 20pm (8pm typical) without artifacts, making the MFP-3D ideal for force measurements such as unfolding single molecules or probing cell mechanics. AFM Is More Than Just Pretty...

From left: Dennis Discher, Florian Rehfeldt, Andre Brown Leadership in Force S pectroscopy and F orce Mechanics • imple setup, calibration, acquisiS tion, display and analysis (any channel vs. any channel) with easy customization for advanced users. “ e chose Asylum’s MFP-3D-BIO AFM because it has the W most powerful AFM capabilities of the inverted optical integrated systems. It excels in all aspects, from optical integration to high-resolution imaging and dimensional measurements to force spectroscopy and elasticity measurements of soft tissue matrices. Asylum’s quality and reliability...

Seamless Optical and AFM Integration The MFP-3D-BIO sets the industry standard for combining optical and atomic force microscopies in a single integrated tool specifically designed for biologists. Our team of biologists and optical e ngineers have optimized the MFP-3D for use with the leading inverted optical microscopes to ensure that you get the maximum benefit and productivity from the combination of these powerful techniques. High numerical aperture, water immersion, and TIRF objectives are all accommodated. No other AFM can match the MFP-3D’s performance for optical integration, high...

Control Your Sample Environment Petri Dish Holder Specially designed sample plate for imaging cultured cells and other biological samples in Petri dishes. “ he MFP-3D-BIO is a research instrument through and T through and designed for the scientist. The optical integration is exceptional, and the flexibility of the platform offers almost endless possibilities.” – Prof. Jan Hoh, Johns Hopkins University Versatility from Above: View, Illuminate, Navigate The MFP-3D extends the capability of the inverted optical microscope by a llowing you to view transparent and opaque samples from above...

The optical path through the head of the MFP-3D-BIO utilizes a high-quality objective which can be used to view the top of opaque samples and to align the laser onto the tip. The objective can also be used as a condenser for brightfield or phase contrast illumination on transparent samples by using a series of lenses and mirrors to illuminate the sample. Using these optical elements, high quality illumination is achieved for observation with the inverted optical microscope objective while not undermining the fidelity of the optical lever or Z-flexure design of the AFM.

For Full Capability and Ease of Use Asylum has made our full capability system easy to learn and use for novices while providing advanced functionality for the most experienced users. Don't compromise your research by choosing an "easy to use"system with limited capabilities. Choose the MFP-3D-BIOfor both full capability and ease of use. Imaging Mode AC mode I Frame Up | Frame Down Base Name Collagen Save Images □ | Save Image] | Browse | Main Panel | Setup | Start with the basics. Press one you, showing a simplified view with only the preset parameters you need for your experiment. Main...

“ ur MFP-3D is a highly reliable and key tool in our NanoImaging O Core Facility. In addition to ‘traditional’ imaging in air, it has outstanding capabilities for imaging in liquid and performing reliable and accurate force measurements. The simplicity of the software allows us to easily train students, yet the open setup of the instrument makes it flexible and powerful for very high-end projects, including nanolithography and nanomanipulation.” – Prof. Yuri Lyubchenko, University of Nebraska Medical Center Yuri Lyubchenko with Luda Shlyakhtenko Real-time Optical Navigation Guide the tip...

Don’t Just Take Our Word For It... Christine Ortiz, Massachusetts I nstitute of Technology “ he MFP has worked great for us. I’ve T used (most other AFM brands) and have found the MFP to be superior for force measurements to all of them. The machine is extremely easy to learn how to use. I have undergrads working on it with no problem. The instrument support is fantastic as well.” Tim Senden, The Australian National U niversity “..that seems to be AR’s trademark. . Great scientists behind great gear. You might think I’m being too effusive, but I haven’t yet started...” Thomas Gutsmann,...