Spirit-NOPA® Broadly Tunable Optical Parametric Amplifiers for 3-Photon Imaging in Neuroscience and Other Ultrafast Scientific Applications The Spirit-NOPA is a family of automated non-collinear optical parametric amplifiers (NOPA) specifically built and optimized for the industry-proven Spirit® HE and Spirit® One™ ultrafast lasers. The turn-key, high repetition rate Spirit femtosecond laser combines with the Spirit-NOPA to create a powerful, user-friendly tunable, high repetition rate source of ultrashort pulses for in-vivo, deep tissue imaging in neuroscience, spectroscopy, and other ultrafast scientific applications. Spirit-NOPA-VISIR delivering unprecedented performance for 3-photon imaging: In combination with our industry-proven Spirit platform, the Spirit-NOPA-VISIR provides an ideal platform for 3-photon excitation microscopy. Spirit-NOPA-VISIR comprises two amplification stages. The first amplification stage is non-collinear, which generates broad bandwidth, and the second amplification stage is collinear, which enables a broad tuning range. Spirit-NOPA-VISIR provides a broadly tunable output of ultrashort pulses with a tuning range of 650 nm to 900 nm (signal) and 1200 nm to 2500 nm (idler), including key wavelengths for deep-tissue, 3-photon imaging. Optionally, the signal output can be compressed down to <70 fs using an external prism-based compressor unit, and the idler output down to <100 fs, using an integrated bulk compressor. Spirit-NOPA Advantage Spirit-NOPA-VISIR: • High pulse energy for 3-photon imaging • Broad tuning range: 650 nm to 900 nm (signal), 1200 nm to 2500 nm (idler) • Optional pulse compression: <70 fs (signal), <100 fs (idler) • Dual pulse length option to bridge the gap in the tuning range Spirit-NOPA (-2H and -3H): • High repetition rate, ultrashort pulses • Wavelength range from UV to near-IR • Integrated pulse compressor • 3-photon excitation microscopy • Single molecules studies • Nanomaterials science • Ultrafast surface dynamics • Mult

Typical Spirit-NOPA-VISIR Performance1 (Pump by a Spirit HE 1040-30 at 30 W and 1 MHz, Compressed Output) The Spirit-NOPA-VISIR is fully computer controlled to enable user-friendly operation. To cover 2P excitation imaging and applications in optogenetics as well, the Spirit-NOPA-VISIR can be configured with a dual pulse length option. With this option, narrow bandwidth, uncompressed laser pulses are available over an extended tuning range of the Spirit-NOPA-VISIR, closing the gap between signal and idler. The dual pulse length option is ideally suited for photostimulation of neurons in optogenetics...

Tuning Range Output Specifications Pulse Width Optional SHG Output Tuning Range Pulse Energy² Pump Requirements4 from Spirit Repetition Rate Wavelength Pulse Energy Max. Input Power Spirit-NOPA-VISIR Output Specifications Tuning Range Conversion Efficiency 650–900 nm (signal) 1200–2500 nm (idler) >10% at peak, when pumped at >20 µJ (uncompressed signal + idler combined) <350 fs uncompressed² <70 fs at 650–900 nm with signal compressor; <100 fs at 1200–2000 nm with idler compressor Compressor Transmission Signal prism compressor: >65% at 650–900 nm Idler bulk compressor: >80% at 1200–2000 nm Optional...

Side View Spirit-NOPA-VISIR Dimensions Side View Side View 1565 Barber Lane, Milpitas, CA 95035 USA PHONE: 1-800-775-5273 1-408-980-4300 FAX: 1-408-980-6921 EMAIL: [email protected] Spirit-NOPA 05/24 ©2024 MKS Instruments, Inc. Specifications are subject to change without notice. [email protected] [email protected] [email protected] [email protected] [email protected] Korea Netherlands Singapore Taiwan United Kingdom [email protected] [email protected] [email protected] [email protected] [email protected] @ 2024 MKS Instruments, Inc....