DriveAFM Next-Level Nanotechnology Tools swiss quality Performance without compromise

Performance without compromise CleanDrive photothermal excitation • Ultra-low noise • Fully motorized system Performance The Nanosurf DriveAFM is the award-winning next generation AFM. It was designed as a system to not only fulfill the demands of today‘s research but to also serve future needs. The ultra-low noise of both the deflection detection system and the CX controller in combination with a direct-drive flexure scanner are the basis for high-resolution imaging - both in air and liquid environments. CleanDrive photothermal cantilever excitation, WaveMode and the full motorization and automated...

Just press PLAY - with Nanosurf Studio Intuitive & easy • Integrated & automated • Configurable • Quarterly updates Intuitive operation Nanosurf Studio is Nanosurf‘s new AFM control software. It takes full advantage of the DriveAFM‘s technical features and thus convinces with its intuitive and easy operation. The system setup including alignment of the optical deflection detection system and the excitation light source as well as the calibration of the cantilever are fully automated. Various imaging modes are just one click away which allows quick switching between different imaging modes. Nanosurf...

Technology inside the DriveAFM Low-noise electronics • Direct drive scanner • Tip-scanning design Ultra-low noise floor The DriveAFM has a very low overall noise floor, which is achieved through a combination of an optimized deflection detection system that integrates a low-noise, low-coherence superluminescent diode and a low-noise, high-bandwidth photodetector, and the low-noise/high-bandwidth CX Controller. This low noise floor allows detecting minute changes in the cantilever ‘s deflection. Moreover, the small laser spot size in combintaion with the low-coherence superluminescent light source...

Ingenious optics design • Small cantilevers • Automated laser & detector alignment The DriveAFM is the first fully motorized AFM system that can be integrated with an inverted optical microscope. Besides the motorized parallel approach, the DriveAFM features fully motorized and software-controlled automatic adjustment of the whole cantilever deflection detection system (beam positioning and detector alignment) as well as the CleanDrive photothermal excitation laser beam position. For optimal performance, the DriveAFM can also adapt the laser focus to the needs of different environments. This...

CleanDrive: Photothermal cantilever excitation Excitation stability at its best NCSTAuD cantilever in air piezo-acoustic excitation photothermal excitation frequency (MHz) AC40 cantilever in buffer solution piezo-acoustic excitation photothermal excitation Photothermal excitation of the cantilever provides unparalleled stability and a high excitation bandwidth in air and liquid environments. Together with the cleanliness of the excitation these benefits allow measurements at multiple frequencies and high-speed applications. Moreover, CleanDrive opens up avenues towards new transformational measurement...

WaveMode: Off-resonance imaging remastered A new AFM mode WaveMode is Nanosurf’s new off-resonance imaging mode using photothermal excitation. The first implementation of photothermal off-resonance tapping (PORT) was set up by Georg Fantner at the EPFL. Since then, WaveMode was developed in collaboration with researchers from ZHAW Zürich and the EPFL to provide a new, simpler implementation of PORT that does not rely on background subtraction for feedback control but uses the amplitude reduction of the cantilever trajectory when interacting with the sample surface. It is the first commercially...

Life science Stability without compromise The DriveAFM plays out all its advantages when it comes to biological applications. Automatic alignment of the beam deflection detection system and full motorization allow adjusting the lasers and photodetector and navigating the sample without interfering with a temperature-controlled environment. CleanDrive provides reliable and clean cantilever tuning in liquid environments. The insensitivity of CleanDrive towards environmental changes, the high sensitivity of small cantilevers, the ease-of-use and force control of WaveMode facilitate imaging of delicate...

WaveMode for life science research Imaging performance on soft and fragile samples WaveMode imaging excels at imaging fragile biological samples that are otherwise difficult or impossible to assess. It allows applying very low imaging forces in a controlled way and at the same time minimizes lateral forces that may displace or disrupt the sample while not compromising on speed or image quality. Using the AFM cantilever as an actuator for WaveMode provides the imaging bandwidth required to maintain imaging speed and performance. Actuating only the cantilever also reduces lateral hydrodynamic drag...

PicoBalance ready Long-term cultivation and optical/fluorescence/mass monitoring of control (unlabeled; left image column) and virus-infected cells (labeled with eGFP; right image column). While the healthy cell grows in mass and divides (dips in the black curve indicate cell division), the infected cell does not change its mass but engages in production of new virus particles (green fluorescence of GFP-labelled virus proteins). Mass measurement is a well-accepted method in many fields of science to characterize systems of any kind. Indeed, mass is typically a well-regulated quantity in biological...

Materials science Versatility without compromise The DriveAFM with its high-performance tip-scanning design is the ideal solution for materials science research. The combination of its unique direct drive tip-scanner technology paired with CleanDrive photothermal excitation and the fast, highresolution and low-noise electronics is key for fast and stable operation in air and liquid. The DriveAFM delivers high-quality images of very small structures like atomic or crystal layer steps, or the atomic lattice of crystalline materials. At the same time, the DriveAFM‘s scanner with its large range...