Solid Fraction Measurement in Pharmaceuticals
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QbD Solid Fraction Analysis in Roller Compaction Operations AccuPyc 1340 Gas Pycnometer GeoPyc 1365 Envelope and T.A.P. Density fitcortir SOP Instrument Maintenance

Solid Fraction Roller compaction is a continuous dry granulation process used to increase the bulk density and uniformity of powders into free flowing granules used in downstream manufacturing operations. It is a complex procedure due to the diversity of available powder blends and the control and adjustment parameters involved in the process. The character and homogeneity of the produced ribbon is controlled by a number of factors, such as the properties of the individual powders themselves, roll speed, roll gap/nip angle, and feed speed; all of which subsequently determine the character...

Envelope Density Analyzer The GeoPyc employs a unique displacement measurement technique that uses Dry Flo, a quasi-fluid composed of small, rigid spheres having a high degree of flow-ability. The sample is placed in a bed of Dry Flo which is agitated and gently consolidated about the sample. The GeoPyc collects the displacement data, performs the calculations, and displays or prints the results. The unit also reports percentage porosity and specific pore volume when absolute density information (density excluding pore and small cavity volume obtained from a Micromeritics AccuPyc II...

Sample Chamber Reproducibility When sample volume is at least 25% of sample holder volume: Typically ± 1.1% Physical Height Electrical Power Electrical Power Environment Temperature *Due to continuous improvements, specifications are subject to change without notice. ACCUPYC II Gas Displacement Pycnometry System ^ 0 j | ■ j ^ ENTER j ^CHOICE j Gas pycnometry is recognized as one of the most reliable techniques for obtaining true, absolute, skeletal, and apparent volume and density. This technique is non-destructive as it uses the gas displacement method to measure volume. Inert gases,...

Gas Displacement Pycnometry On an elementary level, the volume of a solid material can be calculated by measuring its length, width, and thickness. However, many materials have within their structure surface irregularities, small fractures, fissures, and pores. Some of these voids or pores are open to the surface or closed within the structure of the solid material. Therefore, differences in the material volume depend on the measurement technique, measurement method, and the conditions under which the measurements were performed. Interparticle void Particle Volume Principle of Operation...

Highly Adaptive System The AccuPyc II Pycnometer consists of an integrated control and analysis module. For those who require high throughput, analysis modules are also available in a single configuration, allowing you to attach up to five additional analysis modules to a single controlling unit. Each module has its own gas connection. A variety of sample chamber sizes can be selected to provide the best fit with your samples. The run precision mode allows you to achieve high repeatability. The instrument automatically purges water and volatiles from the sample and then repeats the analysis...

Model Selection Hardware Versatility Sample Sample Sample AccuPyc II AccuPyc IIII AccuPyc AccuPyc II AccuPyc II AccuPyc II AccuyPyc II AccuPyc II Bundle AccuPyc II Bundle AccuyPyc II Bundle Remote Analysis Remote Analysis Remote Analysis Remote Analysis Module Only Module Only Module Only Module Only Remote Analysis Remote Analysis Module Only Module Only Remote Analysis Control Module Only Control Module Only Control Module Only Control Module Only Module Only Control Module Only Control Module Only Sample 1-cm Chamber ID x 1.1-cm D 1-cmChamber ID 1.1-cm 1-cm ID1-cmID xx1.1-cm D x 1.1-cm D...

AccuPyc II Specifications Data Presentation The AccuPyc II can be operated with a keypad or an optional Windows® interface that provides exceptional reporting and archiving capability. Both versions include direct sample mass input from a balance and cycle-based displacement volume reporting. With the Windows interface, features such as time-based pressure equilibration reporting and additional calculations such as percent solids content and total pore volume are included. Operational status can also be continually monitored in a status window on the monitor screen. • Combined Report •...

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