Metrohm NIRSystems
16Pages

Metrohm NIRSystems Dedicated near-infrared solutions

Why near-infrared spectroscopy? Near-infrared (NIR) spectroscopy is a versatile analytical technique and a well-known method for rapid, nondes­ tructive analysis on a wide variety of matrices across many industries. In the pharmaceutical and chemical industries, NIR analysis has been successfully implemented for many years, with initial applications focused on raw material testing. More recently, attention has turned to analyzing solid and liquid formulations for final product quality and inprocess control (IPC) of manufacturing operations. In this regard, NIR spectroscopy is a main...

Proven precise NIR technology • 50 patents held by NIRSystems • Full scanning range, visible plus NIR, 400 nm to 2'500 nm Confident in application know-how • 50 years of NIR experience • Laboratory and process application knowledge • Global leader in reference analysis method Dedicated and well-established software • Vision software includes data acquisition, method development, and routine analysis in one package Excellent service and support • Exclusively represented in more than 80 countries, in more than 40 by Metrohm owned subsidiaries • Technical support helpdesk and regional support...

Pharmaceuticals NIR spectroscopy has been utilized in the pharmaceutical industry for many years and is recognized by international pharmacopeias like the United State Pharmacopeia (USP), European Pharmacopoeia (Ph. Eur) and Japanese Pharmacopoeia (JP). NIR applications can be implemented into several Pharmaceutical processes, from raw mat e-rials, to in-process monitoring and control to final product release. Raw materials inspection Compliant to GMP regulations, 100% testing of all incoming raw material containers • Identification of incoming raw materials • Specification control of raw...

Chemistry NIR spectroscopy is sensitive to O-H, N-H, C-H, and S-H bonds. Moisture determination is a common NIR application. Reaction monitoring and endpoint determination using NIR spectroscopy provides real-time results to control the process. Many applications that have historically been measured with physical property testing, like viscosity, may be measured with NIR spectroscopy, if the property is dependent on an intrinsic chemical characteristic, such as chain length or cross linking. Example of NIR applications • Moisture content • Acid value • Hydroxyl number • Adhesive content •...

Education and R&D In petrochemistry, monitoring of the blending process by NIR spectroscopy has proven huge economical savings, since crucial properties such as water content, density, viscosity, additive content, and hydroxyl number can be measured in less than one minute. NIR spectroscopy can be used for different applications in petrochemical process starting from crude oil control, blending process and finished product control. Gasoline parameters • Research octane (RON, ASTM D 2699) • Motor octane (MON, ASTM D 2700) • Road octane number (RdON) • Volume percentage or mole percent of...

And more ... General NIR applications The application specialists of Metrohm NIRSystems have prepared a selection of Application Bulletins and Notes for different industries that show the advantages of the nondestructive NIR method: very fast measurements that require practically no sample preparation and do not need any costly or toxic reagents. This application literature can be downloaded from http://www.metrohm-nirs.com/Applications/

Right choice for successful applications 08 NIR spectroscopy can be used to analyse different types of samples. Choosing the right measurement method, sampling module, and accessories is the most important step to developing robust NIR methods. Sample types NIR measurement methods Diffuse reflection NIR light penetrates into the sample and interacts with the sample. The NIR energy that is not absorbed is reflected back to the detector. • Suitable to measure solid samples without sample preparation Cream, paste, granulates, coarse, fine powders Diffuse transmission NIR light penetrates into...

Examples of right measuring modules for different sampling systems The modular design of Metrohm NIRSystems analyzers ensures that analyses are optimized for specific sample types. NIRS XDS RapidContent,MultiVial, and NIRS DS2500 Analyzer Measured using diffuse reflectance mode • The NIRS XDS RapidContent Analyzer and the Solids Module offer analysis of any solid form • The NIRS XDS MultiVial Analyzer provides the analysis of a tray of solids in vials • The NIRS DS2500 can analyse materials in bags or sample cups, with a rotation feature for non-homogeneous powders NIRS XDS MasterLab...

Laboratory and atline analyzer Metrohm NIRSystems laboratory analyzers with their patented monochromator can be operated in QC, R&D, and plant laboratories. Modular sampling accessories allow for analyses of powders, granules, solids, slurries, gels, pastes, and turbid or clear liquids. Superior analytical performance The patented design of Metrohm NIRSystems analyzers offer unparalleled performance and precise instrument matching to reduce your method development effort, minimize your implementation time and ensure seamless method transferability. Seamless method transferability Shorten...

• Wide range of measuring options for dedicated applications • Hot-swappable modules offers flexibility to expand application anytime with NIRS XDS models • Precise instrument matching, ensures that both quantitative and qualitative methods can be transferred directly from one NIR analyzer to another • Gateway to process • Covers different working conditions: atline, offline, inline, and online • A new level of consistent and reliable instrument performance, integrated diagnostic routines • Analysis while operating in harsh industrial environments Process analyzers The process analyzers...