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Create and control hypercapnia conditions. Life Science - Pharma: Cell Cultures Studies

Create and control hypercapnia conditions. Life Science - Pharma: Cell Cultures Studies
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Create and control hypercapnia conditions. Life Science - Pharma: Cell Cultures Studies - 1

HYPERCAPNIA CONDITION CELL CULTURE DRUGS & PHARMA A SOLID BUSINESS CASE IN COLLABORATION WITH THE INSTITUTE of TECHNOLOGY in LAUSANNE (EPFL) GENERAL INFORMATION ABOUT THE PROJECT Life Science - Pharma: Cell Cultures Studies School of Life Sciences, Laboratory of Microbiology and Microtechnology (LMIC) HEAD OF PROJECT MANAGEMENT: Prof. John McKinney To create and control speciﬁc hypercapnia conditions. MORE INFORMATION ABOUT THE EPFL The École polytechnique fédérale de Lausanne (EPFL) is a research institute and university in Lausanne, Switzerland, that specializes in natural sciences and engineering. EPFL is widely regarded as a world leading university. The QS World University Rankings ranks EPFL 12th in the world across all ﬁelds in their 2017/2018 ranking, whilst Times Higher Education World University Rankings ranks EPFL as the world's 11th best school for Engineering and Technol

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Create and control hypercapnia conditions. Life Science - Pharma: Cell Cultures Studies - 2

DESCRIPTION OF THE APPLICATION AND THE TARGET Nonreplicating and metabolically quiescent bacteria are implicated in latent tuberculosis infections and relapses following ‘‘sterilizing’’ chemotherapy. However, evidence linking bacterial dormancy and persistence in vivo is largely inconclusive. Here we measure the single cell dynamics of Mycobacterium tuberculosis replication and ribosomal activity using quantitative time-lapse microscopy and a reporter of ribosomal RNA gene expression. Single-cell dynamics exhibit heterogeneity under standard growth conditions, which is ampliﬁed by stressful...

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