A SOLID BUSINESS CASE IN COLLABORATION WITH THE “UNIVERSITAT DE BARCELONA “ CeLL Study - Mimicking Obstructive SLeep Apnea DEPARTMENT: Unitat de Biofisica i Bioenginyeria, FacuLtat de Medicina, HEAD OF PROJECT MANAGEMENT: DanieL Navajas ROLE OF MCQ INSTRUMENTS: To create and control, specific hypoxic environments. MORE INFORMATION ABOUT THE HEAD OF THE PROJECT Daniel Navajas, Ph.D. Professor of Physiology, Unit of Biophysics and Bioengineering, Department of Physiological Sciences I, School of Medicine, University of Barcelona. Group Leader, Institute for Bioengineering of Catalonia (IBEC). Academic Director, Degree in Biomedical Engineering, University of Barcelona

DESCRIPTION OF THE APPLICATION AND THE TARGET Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), plays a critical role in the pathogenesis of OSA associated morbidities, especially in the cardiovascular and respiratory systems. Oxidative stress and inflammation induced by IH are suggested as main contributors of end-organ dysfunction in OSA patients and animal models. Since the molecular mechanisms underlying these in vivo pathological responses remain poorly understood, implementation of experimental in vitro cell-based systems capable of inducing high-frequency IH would...