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UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System

UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System

UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System

Product catalog summary
Overview of UV15X-6Med-2
UV15X-6Med-2 is a UV-curable system known for its flexibility, toughness, and strong adhesion to various substrates. It cures quickly under UV light and is biocompatible, making it suitable for encapsulating implantable devices like wireless vagus nerve stimulation systems.
Application
The case study focuses on a closed-loop, fully-automated wireless vagus nerve stimulation (FAW-VNS) system developed by UCLA. This system includes a miniaturized, wirelessly-powered implant encapsulated with UV15X-6Med-2 to ensure safety and reliability by protecting electronics from moisture and corrosion.
Key Parameters and Requirements
The implant consists of a flexible polyimide board with various components, including a stimulator chip and wireless power transfer coil. These components are protected by UV15X-6Med-2, which acts as a biocompatible, electrically insulating barrier.
Results
UV15X-6Med-2's protective capabilities were tested through prolonged immersion in phosphate-buffered saline (PBS), simulating physiological conditions. The encapsulated device maintained consistent performance over 20 days, indicating effective protection against corrosion.
In-vivo Tests
The system was implanted in four anesthetized pigs, demonstrating reduced heart rate drops and maintaining stimulation above the nerve activation threshold. The system adjusted parameters automatically, showcasing its closed-loop control capabilities.
Conclusions
The study presents FAW-VNS as a pioneering batteryless, fully automated wireless vagus nerve stimulation system. Encapsulation with UV15X-6Med-2 ensured long-term stable operation by preventing bodily fluid intrusion, supporting the device's consistent performance.
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Catalog excerpts

UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System-1

&MASTERBONDCASE STUDY UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System Master Bond Inc. 154 Hobart Street, Hackensack, NJ 07601 USA Phone +1.201.343.8983 | Fax +1.201.343.2132 | [email protected]

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UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System-2

CASE STUDY UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System Overview of UV15X-6Med-2 UV15X-6Med-2 is a one-component, medium-viscosity UV-curable system that offers high flexibility, toughness, abrasion resistance, and strong adhesion to substrates including glass, polycarbonates, acrylics, plastics, metals, and rubbers. It cures within 10-30 seconds under 320-365 nm UV light and provides excellent toughness, optical clarity, and electrical insulation. Its biocompatibility (passes USP Class VI and ISO 10993-5 cytotoxicity testing) and water resistance...

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UV15X-6Med-2: Used as a Biocompatible Encapsulant for a Wireless, Nerve Stimulation System-3

UV15X-6Med-2 generally cures in 10-30 seconds at ambient temperatures when exposed to 320-365 nm UV light, and can cure in sections approaching 1/4 inch thick without oxygen inhibition. Results The protective function of UV15X-6Med-2 was evaluated by prolonged immersion in phosphate-buffered saline (PBS) to simulate physiological conditions. The salt content of PBS is challenging for electronics because it accelerates corrosion and mimics the ionic conductivity of bodily fluids. Despite continuous exposure to PBS for 20 days, the device maintained consistent stimulation (Figure 2) throughout...

 Open the catalog to page 3

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