Zetasizer Core Complete stability. One platform.

Next-generation biophysical screening, at scale Early stability decisions shape the future of a biologics pipeline. Yet fragmented workflows, isolated measurements, and misaligned data slow progress— making late-stage aggregation and stability issues exceptionally costly. A new era in biologics characterization is here Accelerate your biologics discovery and development with the Zetasizer Core – an all-in-one platform engineered for high-throughput biophysical stability screening, with no compromise between throughput and data quality. As the first system to combine dynamic light scattering (DLS),...

Inside the Zetasizer Core Zetasizer Core accelerates stability screening by combining structural, colloidal and aggregation analysis in a single workflow— turning screening complexity into confident decisions. Exceptional data quality at scale: Industry-leading precision for confident, high-throughput decision-making Multi-parameter stability insights: Simultaneous measurement of size, colloidal stability, and structural stability Advanced thermal control: Precise knowledge of the plate’s thermal profile ensures absolute data reproducibility Microwell plate compatibility: Seamless integration...

Comprehensive stability insights, all on one platform Assess structural and colloidal stability, aggregation risk, and formulation robustness— all in a single run. • DSF capabilities for label-free thermal unfolding analysis, tracked via native fluorescence with no added reagents • Dedicated SLS optical path for precise quantification of protein self-association and repulsion (B22 / A2), transforming what was once an expert-only measurement into a routine screening tool • DLS for hydrodynamic size, polyd ispersity, and early aggregation detection Streamlined, open-architecture designFull compatibility...

Gold-standard stability screening across every stage of biologics development Static light scattering (SLS): Colloidal stability and thermal aggregation High-throughput dynamic light scattering (DLS): Aggregation and size screening • Thermal aggregation (Tagg): Monitor Identify thermal aggregation, quantify absolute molecular weight, and map self-association behavior using SLS. The system measures average scattered light intensity to deliver clear, direct insights into colloidal stability, helping you confidently de-risk formulation development and candidate selection. Track hydrodynamic size...

Engineered for confidence at every stage Zetasizer Core comes in two models: Our flagship model combines the colloidal insights of DLS and SLS with the powerful structural data of DSF. Sizing and aggregate measurements are enabled seamlessly across automated thermal ramps, mapping physical particle changes directly to structural unfolding events from DSF. Measure both physical aggregation and thermal stability (unfolding) in a single run. Biotherapeutic pre-formulation screening, early-stage candidate selection, structural biology R&D, and high-throughput profiling where tracking thermal denaturation...

ProteinsAccelerate therapeutic protein developability and formulation decisions. For therapeutic proteins, the Zetasizer Core supports early and confident evaluation of stability, aggregation, and formulation robustness. By screening multiple candidates, buffers, and stress conditions in a scalable, high-throughput plate-based format, scientists can identify promising molecules earlier and significantly reduce the risk of late-stage instability. • Candidate selection & lead optimization: Rank variants early based on robust physical stability profiles. • Early developability assessment: Flag problematic...

Malvern Panalytical provides market-leading, material characterization technologies for the world’s most innovative companies, academic institutions, and government laboratories to optimize and accelerate the development of advanced materials. We support our customers through their biggest challenges by uncovering critical insights in material properties. From developing lifesaving vaccines and next-generation therapeutics to advancing clean energy solutions and sustainable industrial processes, we give scientists the confidence to make important decisions that shape the world we live in. We...