PEAQ-ITC Systems MicroCal technology Understanding biomolecular interactions

Used widely in life sciences and drug discovery Thousands of citations in reference databases illustrate the diverse application of Malvern Panalytical PEAQ-ITC systems. ITC is a powerful technique used to determine the binding affinity and thermodynamic properties of any biomolecular change that can influence recognition between binding partners. When combined with structural information, PEAQ-ITC data provides deeper insights into structure-function relationships and the mechanisms of binding. While the following examples provide a snapshot, you can find a wealth of detailed applications information...

Understanding biomo interactions better O r' a \ T Isothermal titration microcalorimetry Isothermal titration microcalorimetry (ITC) is an essential tool in drug discovery and protein interaction research. Having been developed specifically to meet the needs of life scientists working in these fields, Malvern Panalytical's PEAQ-ITC deliver the exceptional performance and outstanding quality data needed in these application areas. PEAQ-ITC systems directly measure the heat released or absorbed during a biomolecular binding event. The result is a direct, label-free measurement affinity, stoichiometry...

Isothermal titration calorimetry determines thermodynamic properties that tell you why interactions occur. Thermodynamic data reveal the forces that drive complex formation to describe function and mechanism at a molecular level. The benefits of ITC • Label-free measurement - ensures analysis of unaltered biomolecules in their native state giving a true picture of behavior. • Ease of use – quick to first result with minimal assay development, no labelling, no immobilization and no molecular weight limitations. • Broad dynamic range - measurement of molecules in solution preserves biological relevance...

glance PEAQ-ITC PEAQ-ITC, a MicroCal technology, is designed for ease-of-use and exceptional sensitivity. The wide affinity range enables analysis of weak to high affinity binders, with excellent reproducibility. PEAQ-ITC analysis software offers experiment design simulation, batch evaluation of large data sets, automated assessment of data quality and a streamlined user interface that guides the user to final figures and presentation quality graphs quickly and easily. PEAQ-ITC is an essential tool for any research laboratory studying biomolecular interactions where high sensitivity and fast...

PEAQ-ITC range at a glance PEAQ-ITC Automated Combining exceptional performance of the PEAQ-ITC with full automation and unattended operation, the PEAQ-ITC Automated is a valuable asset for any busy research laboratory. User-friendly software ensures efficient experimental design while automated data analysis delivers fast, reliable results. The automation and throughput it offers make it a particularly good choice for drug discovery applications such as hit validation where productivity is crucial. Features: • Fully automated with capacity to run four 96-well plates unattended • Append new experiments...

User-friendly software for fast and accurate analysisUser-friendly software for fast and accurate analysisInstrument control software that takes you from experiment to Experimental setup step-by-stepfinal results: PEAQ-ITC instrument control software incorporates all the tools you need to go from experimental design to final results quickly and easily. Overview Adjust Baseline Assign Controls Adjust Fit Scatter Plot Injection Table Statistics Plot Signature Plot Raw Plot Integrated Heat Plot Molar Ratio Molar Ratio Molar Ratio Guided work-flows User-friendly guided workflows with embedded help...

Specification comparison summary The PEAQ-ITC instrument response time is a true time constant. It is the time interval between the first deviation away from the baseline, and the point on the peak that is 63% of the maximum peak height.

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