MICROCAL PEAQ-DSC Biomolecular stability analysis for the regulated environment

INTRODUCTION TO DIFFERENTIAL SCANNING CALORIMETRY (DSC) WHAT IS DSC? Differential Scanning Calorimetry (DSC) is a powerful analytical technique which characterizes the thermal stability of proteins and other biomolecules. In solution, these molecules often undergo thermally-induced conformational changes, such as the breaking of non-covalent bonds leading to the unfolding of a protein. These types of structural rearrangement are detectable by DSC as they require the absorption of energy in the form of heat. Even in dilute solutions of protein, the new MicroCal PEAQDSC systems detect such heat...

MICROCAL PEAQ-DSC MICROCAL PEAQ-DSC AUTOMATED MicroCal PEAQ-DSC MicroCal PEAQ-DSC Automated The MicroCal PEAQ-DSC system provides highly sensitive, easy-to-use microcalorimetry that helps reduce the time and cost associated with stability testing and comparability analysis. This is a manual instrument with a cleaning device, which can be upgraded to the automated version upon request. This complete system requires no additional accessories, reagents or consumables. The integrated software and automated data analysis support the generation of non-subjective, highly reproducible thermal stability...

PEAQ-PERFORMANCE21 CFR Part 11 and Annex 11 Compliance software: Keep your system performing perfectlyDSC for the regulated environment The all-new MicroCal PEAQ-DSC software is available with an optional 21 CFR Part 11 compliance module. This makes both MicroCal PEAQ-DSC systems perfect for QC-type work, including root cause analysis and in-process measurements. Malvern has a wealth of experience working in cGxP environments. We understand the need for easy-to-use analytical systems that enable robust method development and transfer, with the support of 21 CFR Part 11 and also Annex 11 compliance...

PEAQ-COMPAREEasy experimental set-up, fast and intuitive data analysis and report generationDirectly compare DSC thermograms, between molecules and between batches PEAQ-Smart provides new and improved control and data analysis for faster experimental design and implementation. Embedded videos are included to give a visual overview of DSC experimental design and also guide maintenance of the system - these help users of every level proceed with confidence. In addition, a new PEAQ-Smart report designer is included. An SOP-Builder is built-in, to guide and accelerate experimental setup and provide...

11PRODUCT SPECIFICATIONS AT A GLANCE Parameter 1Sample dependent; 2Typical results for ribonuclease (RNase) in 50 mM KAc buffer at pH 5.5, at 60°C/h with high feedback; 3Rescans of a stable buffer; 4Using ribonuclease (RNase); 5Range may be extended down to -10°C upon request

WHY CHOOSE MALVERN PANALYTICAL? We are global leaders in materials characterization, creating superior, customer-focused solutions and services which supply tangible economic impact through chemical, physical and structural analysis. Our aim is to help you develop better quality products and get them to market faster. Our solutions support excellence in research, and help maximize productivity and process efficiency. Malvern Panalytical is part of Spectris, the productivity-enhancing instrumentation and controls company. www.spectris.com SERVICE & SUPPORT Malvern Panalytical provides the global...