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Malvern OMNISEC - Resolve, Reveal, Realize

Malvern OMNISEC - Resolve, Reveal, Realize
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Malvern OMNISEC - Resolve, Reveal, Realize

Product catalog summary
Introduction
Malvern's OMNISEC is a comprehensive solution for gel permeation/size exclusion chromatography (GPC/SEC), designed to characterize synthetic and natural polymers, as well as proteins. It integrates systems, detectors, and software to provide sensitive and accurate measurements of molecular weight, intrinsic viscosity, and sample concentration.
OMNISEC Components
  • OMNISEC RESOLVE: Combines a pump, degasser, autosampler, and column oven for efficient sample separation.
  • OMNISEC REVEAL: A multi-detector module with refractive index, UV/Vis absorbance, light scattering, and viscosity detectors for comprehensive characterization.
  • OMNISEC Software: Version 10 offers an intuitive interface to simplify GPC/SEC analysis, enhancing productivity.
Key Features and Benefits
  • Temperature-controlled autosampler and column oven for sample protection and improved resolution.
  • Advanced light scattering detector for low molecular weight and concentration measurements.
  • Efficient degasser and low-pulsation pump for stable baselines and reduced noise.
  • User-exchangeable viscometer capillary module for reduced service time and cost.
Applications
OMNISEC is used in industries such as pharmaceuticals, biopharmaceuticals, food and drink, and cosmetics to understand polymer characteristics, control drug release, and ensure product quality.
Software and Support
The OMNISEC software streamlines the GPC/SEC workflow with customizable reporting, easy data export, and intuitive navigation. Malvern provides extensive support, including validation tools, training courses, and a global service network.
Specifications
The document details the specifications of the OMNISEC system, including the OMNISEC REVEAL and RESOLVE components. Key parameters include concentration, molecular weight, polydispersity, and intrinsic viscosity. The system is suitable for synthetic and natural polymers, as well as proteins.
Recommended Computer Specifications
A Windows 7 Professional 64-bit system with a 4th Gen Intel® Core I7 Processor, 8 GB RAM, and a 500 GB HDD is recommended.
Data Collection and Patents
The system collects data at a rate of 100 Hz and is protected by patents such as US 14/599,033 and EP2619543B1.
OMNISEC REVEAL Specifications
- Dimensions: 42 x 64 x 60 cm, Weight: 40 kg, Power: 600 W
- Detector temperature control range: 20 - 65°C
- Differential refractive index detector with a dynamic range of ±2.5 x10-4 RIU
- Diode-array-based UV/Vis spectrometer with a wavelength range of 190 - 900 nm
- Light scattering detector with a molecular weight range of 200 - >107 g/mol
OMNISEC RESOLVE Specifications
- Dimensions: 42 x 64 x 89 cm, Weight: 62 kg, Power: 600 W
- Isocratic pump with a flow rate range of 0.005 - 10 mL/min
- Autosampler capable of handling up to 192 samples with temperature control from 4 - 60°C
- Column oven with a temperature control range of 20 - 65°C
General Information
Malvern Instruments Limited, part of Spectris plc, provides this system. Specifications are subject to change due to continual improvement efforts.
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Catalog excerpts

Malvern OMNISEC - Resolve, Reveal, Realize-1

IRKS} MOLECULAR STRUCTURE ^ RESOLVE, REVEAL, REALIZE

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Malvern OMNISEC - Resolve, Reveal, Realize-2

Resolve, reveal, realize OMNISEC - A NEW STANDARD IN GPC/SEC Malvern’s OMNISEC is a complete gel permeation/size exclusion chromatography (GPC)/(SEC) solution consisting of systems, detectors and software. Malvern’s expertise has enabled the development of the most sensitive and accurate multi-detector GPC/SEC system for the characterization of synthetic and natural polymers, and proteins. OMNISEC can accurately measure the most important characterization parameters including: • Absolute molecular weight and molecular weight distribution • Intrinsic viscosity and molecular structure • Sample...

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Malvern OMNISEC - Resolve, Reveal, Realize-3

Resolve, reveal, realize OMNISEC - AT A GLANCE The complete, integrated OMNISEC solution is made up of 3 components: OMNISEC RESOLVE - an integrated pump, degasser, autosampler and column oven for managing the separation in a single advanced separations unit. OMNISEC REVEAL - an integrated multidetector module for the characterization of synthetic and natural polymers, and proteins: • The most sensitive light scattering detector in the world • Unrivalled baseline stability on all detectors for greater sensitivity to low concentrations of sample • Self balancing viscometer detector • Wide UV/VIS...

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Malvern OMNISEC - Resolve, Reveal, Realize-4

Resolve, reveal, realize OMNISEC RESOLVE AND OMNISEC REVEAL The complete GPC/SEC solution OMNISEC RESOLVE has been designed using our 30 years of experience in GPC/ SEC and precision electronics to achieve the highest possible standard in chromatographic performance. The efficient degasser, lowpulsation pump, outstanding autosampler and large capacity column oven combine to give reduced baseline noise and improved stability to maximize measurement sensitivity and accuracy. OMNISEC REVEAL is the integrated multi-detector platform. It is available with refractive index, full range UV/Vis photodiode...

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Malvern OMNISEC - Resolve, Reveal, Realize-5

Resolve, reveal, realize INTRODUCTION TO TECHNIQUE AND TECHNOLOGY Absolute Molecular Weight, Molecular Size The highest quality GPC/SEC measurement requires two things: • a good separation of the sample RESOLVE • sensitive detectors to characterize the separated sample - REVEAL GPC/SEC Separation As the dissolved sample flows through the porous column matrix, the individual molecules diffuse in and out of the pores. Larger molecules are excluded from more pores, and so travel through the column faster, eluting earlier while the smaller molecules elute later. The result is a separation by hydrodynamic...

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Malvern OMNISEC - Resolve, Reveal, Realize-6

Resolve, reveal, realize SYNTHETIC AND NATURAL POLYMERS Absolute Molecular Weight, Molecular Size, Structure Product performance Take control of polymer performance For both synthetic polymers and natural polymers, product performance is key to your success. For example: GPC is used in many industries as a development and QC tool. With a full understanding of your polymer’s characteristics: • If a polymer molecular weight changes from the specification, it may be too weak or too difficult to process • The polymer manufacturer can appropriately grade and sell their product • Poor control of PLA/PLGA...

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Malvern OMNISEC - Resolve, Reveal, Realize-7

Resolve, reveal, realize OMNISEC RESOLVE Integrated separations module OMNISEC RESOLVE is a combined pump, degasser, autosampler and column oven for mobile phase delivery and sample injection. What benefits does a complete GPC/SEC system that includes OMNISEC RESOLVE provide? • A complete solution from a single manufacturer with an intuitive software package that handles everything from instrument control to data acquisition and data analysis • Unattended operation using the autosampler, even with sensitive samples such as proteins, thanks to its temperature control FEATURES OF OMNISEC RESOLVE...

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Malvern OMNISEC - Resolve, Reveal, Realize-8

Resolve, reveal, realize OMNISEC REVEAL Integrated multi detector module OMNISEC REVEAL is an integrated multi-detector module for advance GPC/ SEC measurements incorporating refractive index, UV/Vis absorbance, light scattering and intrinsic viscosity detectors. The high sensitivity and measurement quality that it provides ensures maximum return on your investment. It can act as a stand alone detector connected to your existing GPC/SEC system or as a complete GPC/SEC solution in combination with the OMNISEC RESOLVE module. Refractive index Intrinsic viscosity An integrated design keeps all of...

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Malvern OMNISEC - Resolve, Reveal, Realize-9

Resolve, reveal, realize DEDICATED INTUITIVE SOFTWARE Designed with the GPC/SEC workflow in mind Workflow oriented software OMNISEC software v10 has been designed with you and your priorities in mind. It makes GPC/SEC analysis as easy and intuitive as possible. The software is laid out to guide the user through setup, data acquisition and analysis in an intuitive workflow. The software's advanced user interface reduces training requirements for new users. Software features Key features that make multi-detector analysis more valuable than ever include: • Intuitive look and feel based upon the...

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Malvern OMNISEC - Resolve, Reveal, Realize-10

Malvern’s materials characterization technology and expertise enables scientists and engineers to understand and control properties of dispersed systems. Malvern’s instruments are used to measure particle size, particle shape, zeta potential, molecular weight, size and conformation, rheology and for chemical identification. This information helps accelerate R&D, enhance product quality, optimize process efficiency. Excellence through experience World-class service and support Malvern offers professional support at all levels. Our intention is to increase your laboratory’s productivity through...

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Malvern OMNISEC - Resolve, Reveal, Realize-11

Resolve, reveal, realize SPECIFICATIONS OMNISEC Molecular Characterization System OMNISEC Molecular Characterization System Parameter OMNISEC REVEAL CONT. OMNISEC SYSTEM Parameters measured Concentration, dRI, dn/dc, dUV, dA/dc, Light scattering intensity (SLS), Molecular weight (Mn, Mw, Mz), Polydispersity, Radius of Gyration, Intrinsic viscosity, Mark-Houwink a & K, Hydrodynamic radius (viscosity) Sample types Recommended computer specification Data collection rate 4-capillary Wheatstone bridge with self-balancing mechanism and userexchangeable capillaries Differential pressure dynamic range...

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