LEWA EcoPrime - The custom-designed chromatography system

Product catalog summary

Introduction
The document provides an overview of the LEWA EcoPrime® chromatography system, designed for pharmaceutical and biopharmaceutical applications. It highlights the system's capabilities in downstream processes such as purification of monoclonal antibodies, vaccines, recombinant proteins, and hormones.

Specifications and Features
The LEWA EcoPrime® system is equipped with LEWA ecodos® hygienic pumps and LEWA intellidrive® technology, offering precise, low-pulsation flow. Key features include:

Unrivalled accuracy and constant back pressure for increased precision.
Dynamic flow range of 1:150 and significant reduction in pulsation and holdup volume.
Design conformity with pharmaceutical requirements and advanced bubble trap design for optimal degasification.
Capability for 1 to 99% step and linear gradient, CIP able, and optional SIP capability.

System Design and Functionality
The system bridges research, development, and production stages, combining process-relevant accessories and ensuring high reliability. It features self-cooling, ventilation-free pump motors and offers a comprehensive control system divided into modules, sequences, and operations for various chromatography processes.

Customization and Compliance
LEWA offers custom-designed solutions to meet specific production requirements, ensuring compliance with international standards such as API, ASME, GOST-R, FDA, EHEDG, and 3A. The system is compatible with SCADA systems and supports CFR 21 part 11 compliance.

Performance and Validation
LEWA provides documentation for material traceability and system validation, offering IQ/OQ documentation and execution, cGMP compliance, and on-site qualification services. The system's intelligent drive enhances pump precision to ± 0.5% and maximizes flow range.

Applications and Expertise
LEWA has over 50 years of experience in metering pumps and systems, offering solutions for various industries including oil & gas, petrochemicals, pharmaceuticals, and food & beverages. The company provides comprehensive services from process analysis to global service, ensuring high process safety and low lifetime costs.

Catalog excerpts

LEWA EcoPrime - The custom-designed chromatography system-1

A MEMBER OF NIKKISO Creating Fluid Solutions ^^h^^h pumps + Systems 30450189 ASME BPE-2009 prcise wide dynamic range minimum pulsation lowest holdup volume low shear to process biomolecules

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LEWA EcoPrime - The custom-designed chromatography system-2

r LEWA EcoPrime® - for liquid low-pressure process chromatography for pharmaceutical and biopharmaceutical applications, e.g. downstream processes with LEWA intellidrive* technology of monoclonal antibodies, vaccines, recombinant proteins, and hormones LEWA developed the first pulseless process pump for liquid chromatography in the 1970s. Since then LEWA has been a leader in pumps used for pilot and industrial process chromatography worldwide. In com-bination with the LEWA intellidrive technology LEWA EcoPrime brings low-pulsation flow and accuracy to modern chromatography as a unique feature....

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LEWA EcoPrime - The custom-designed chromatography system-3

For spcifie requirements - Systems with LEWA intellidrive® technology for your process Main control screen -visualization and touch screen LEWA has four platforms to meet your downstream requirements. samples. This allows better symmetry and reduces back mixing. LEWA provides all documentation to show that the materials used to build the system are all traceable back to their original sources. Moreover all plastic materials are USP Class VI certified. Regulatory authorities expect manufac-turers of pharmaceuticals to qualify equipment before use in production. LEWA can provide you with validation...

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LEWA EcoPrime - The custom-designed chromatography system-4

A MEMBER OF NIKKIS Creating Fluid Solutions pumps + Systems LEWA proven services and technologies Germany / Headquarters S LEWA GmbH Ulmer Str. 10 71229 Leonberg Phone +49 7152 14 - 0 Fax +49 7152 14 -1303 [email protected] www.lewa.de Japan / Headquarters S NIKKiso Co. LTD. Yebisu Garden Place Tower 22nd Floor 20-3, Ebisu 4-Chome, Shibuya-ku Tokyo 150-6022 Phone +81 3 3443 - 3711 Fax +81 3 3473 - 4963 www.nikkiso.com Contacts of LEWA's numerous affiliated companies and' w representatives can be found on ' www.lewa.com Customized solutions for metering and process technology For more than 50 years,...

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