Solutions for Metabolomics Analysis EMPOWERING RESULTS

The Established Leader in GC-MS Metabolomics Metabolomics presents challenges for both the analytical methods used and the data reduction required to interpret the results. No single analytical technique can be used for complete characterization of the metabolome, and no metabolome has been completely characterized. However, GC-MS provides an established method to analyze the primary metabolome, whereas LC investigates the secondary and tertiary metabolites. 1-4 As the established leader in GC-MS metabolomics , LECO products deliver the accuracy, resolving power, deconvolution, and speed to characterize...

Pegasus BT GC-TOFMS A proven quantitative and qualitative workhorse, the Pegasus BT GC-TOFMS is a staple of leading metabolomics laboratories. The high sensitivity, peak capacity, and reproducibility of GC combined with Timeof-Flight Mass Spectrometry (TOFMS), provides bene ts such as reduced analysis times, industry-leading peak deconvolution, and an ability to re-interrogate rich data sets repeatedly for biological inference. ® LECO's innovative StayClean Ion Source design virtually eliminates the need to clean your source—lowering downtime and enhancing productivity. Furthermore, the metabolomics...

Pegasus BT 4D GCxGC-TOFMS: See What Else is in Your Sample The complexity of biological samples often presents one of the biggest challenges to increasing our knowledge. Having the availability of increased separation space allows the scientist to unlock more information from the samples without the possible bias and time investment of additional sample preparation. A pioneer in comprehensive two-dimensional gas chromatography, LECO empowers metabolomics researchers worldwide looking for answers to the question, “What else is in my sample?” The example below shows how the second dimension of...

In addition to the increased identification capabilities and peak capacity, cryogenic focusing occurs at the modulator to sharpen the peaks prior to detection with MS. This enhanced peak detectability is illustrated with arachidonic acid, trimethylsilyl ester, shown below in overlaid one-dimensional and twodimensional data. Less abundant analytes are enhanced significantly, typically analytes which are below the detection limit with one-dimensional chromatography. These benefits combine to offer a more complete picture of a sample relative to GC alone. It has been repeatedly proven in academic...

High Resolution GC-MS: the Pegasus GC-HRT With unknown metabolites presenting one of the most signi cant challenges to the metabolomics community, having tools to facilitate unknown identi cation is pivotal to advancing biological studies. High Resolution GC-TOFMS gives you more con dence in identi cations and a tool to identify your most challenging unknowns. Our high resolution MS, deconvolution, and novel data acquisition system deliver revolutionary capabilities to the metabolomics marketplace. These capabilities result in mass accuracies which minimize the uncertainty in identi cation. Accurate...

Conårm Your EI Library Match with Soft Ionization Library Match 679/1000 Anhydro-sorbitol (TMS) = C18H44O5Si4 As universal and data rich as HR-EI is, there can still be ambiguity as to molecular ion identi cation. High Resolution Chemical Ionization (HR-CI) can provide a solution to this problem by delivering a softer ionization mechanism for preservation of the molecular ion, which can then be used to formulate a calculation in its own right, and to lter the possible library hits provided by the EI spectral library search from seven possible identi cations to one clear known. Win the Fight Against...

LECO's Commitment to Quality and Service Every day around the world, LECO instruments continuously perform analyses for today's most complex applications. Whether you are analyzing samples in the food, flavor/fragrance, petroleum, environmental, or life science (metabolomics) industries, we have an instrument configuration to meet your needs. Technical Research Center Customer Demonstration and Application Center Our global network of sales/support includes over 25 subsidiaries worldwide, and is dedicated to customer service and satisfaction. Our commitment to quality is further underscored with...