Granulation technology by Bohle
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GRANULATION Wet Granulation | Dry Granulation

TABLET COATING HANDLING WEIGHING & DOSING GRINDING & SIEVING Accurate weighing helps manage raw materials, meet regulatory requirements and improve product quality. Worldwide, L.B. Bohle's grinding and sieving machines are recognized as the most advanced for precision particle size reduction according to industry standards. The technology-leading coaters from L.B. Bohle guarantee first-class product processing with high profitability. Perfect handling is a key factor in optimizing production processes. GRANULATION BLENDINGCONTINUOUS MANUFACTURING L.B. Bohle offers a comprehensive range of...

BFS Fluid Bed System Fluid Bed Granulator & Fluid Bed Dryer L.B. Bohle developed the BFS fluid bed system with tangentially mounted spray nozzles for batch sizes from 1 to 500 kg. Since the BFS fluid bed systems can withstand pressure surges of up to 12 bar, they are suitable for both water-based and organic solvent processes. Short product transfer times and convenient and effective cleaning offer additional savings in production time and costs. A minimum of six filter elements, which can be cleaned separately, ensure that the air flow through the product bed is not interrupted. The...

BFS FLUID BED SYSTEM The L.B. Bohle BFS fluid bed system with tangentially mounted spray nozzles guarantees first-class technology for granulation, coating, and drying. The innovative Bohle Uni Cone BUC® technology ensures complete fluidization, resulting in uniform coating results and high yields due to the absence of particle twinning in the product. Advantages: y/ Uniform coating, no twin formation y/ Pressure shock resistance up to 12 bar - ideal for containment applications y/ PAT, NIR and WIP integration y/ Patented filter cleaning - patented diffuser y/ Low height, efficient use of...

The compact module is the effective solution for optimizing classical wet granulation and drying in an economical and ergonomic way. The individual components - GMA high-shear granulator, BTS wet screen, BFS fluid bed, Bohle Uni Cone BUC®, cyclone separator and BTS dry screen - are optimally combined in a single unit. Process, cleaning, control, explosion protection, zone concept and qualification are perfectly coordinated. Small footprint, high quality By positioning the components directly next to each other, the compact module enables particularly space-saving installation. In addition,...

GMA HIGH-SHEAR GRANULATOR The GMA High-Shear Granulator is a granulation system specifically designed for pharmaceutical applications. The high-shear, high-compaction impeller blade ensures effective granulation. The chopper prevents excessive granule growth and distributes the granulating liquid throughout the product. Advantages: Low liquid consumption Easy discharge Closed system Granulation can be controlled by time, volume, or power Effective cleaning and complete draining of water TECHNICAL DATA High-Shear Granulator Chopper [rpm] Torque measurement at impeller Control 150 – 1500,...

VMA SINGLE-POT GRANULATOR The VMA Single-Pot Granulator is a granulation system optimized for pharmaceutical applications. The three process steps of mixing, high-shear wet granulation and drying (vacuum drying, carrier gas drying or microwave heating) are performed in a single process bowl. Advantages: ✓ Small footprint Installation in hazardous areas ✓ High mixing and granulation efficiency, Low temperature vacuum drying even at low active ingredient levels (< 1%) >/ Batch sizes from 20 to 960 liters Single-Pot Granulator Batches [l] Impeller [rpm] Chopper [rpm] Liquid dosing Temperature...

With the QbCon® 1, L.B. Bohle offers the optimal entry into Continuous Manufacturing. Our truly continuous wet granulator and dryer for research and development guarantees improved product quality while increasing flexibility and operator safety. In addition, costs are saved by using fewer resources, and development cycles are shortened through the use of process analytics. In contrast to competing systems, QbCon® 1 enables a permanent, truly continuous process without the formation of sub-batches and blocked filters. QbCon® 1 - The Truly Continuous Way Advantages: >/ Material flow from the...

The share of continuous manufacturing systems in the pharmaceutical is increasing visibly. With QbCon® WG 25, L.B. Bohle offers a system that realizes truly continuous wet granulation and drying for a throughput of 25 kg/h. Advantages: V Reduces process time by >50% compared to traditional granulation and drying process y/ Better product quality y/ Closed process y/ Introduction of a continuous process in a batch context (bin-to-bin) y/ Better process visibility and faster problem identification y/ Less scrap in case of malfunction y/ Approximately 60% less product contacting surface...

BRC - ROLLER COMPACTOR L.B. Bohle meets the increasing market demands for continuous processes with the BRC 25 and the BRC 100, an innovative dry granulator with gap control. The BRC enables high production capacity with minimal material loss. This is achieved by fast and precise force control of the compacting rolls with a purely electromechanical roller drive. The BRC controls the gap thickness very innovatively and produces uniform compacting of the material over a wide production range from < 1 up to 400 kg/h. Advantages: Hygienic design and effective cleaning with integrated WIP...

L.B. Bohle Maschinen und Verfahren GmbH Industriestr. 18 D–59320 Ennigerloh +49 25 24 93 23 0 info@lbbohle.de www.lbbohl