L.B. BOHLE - INNOVATIVE MACHINES AND PROCESSES FOR THE PHARMACEUTICAL INDUSTRY WEIGHING & DOSING Accurate weighing helps manage raw materials, meet regulatory requirements and improve product quality. GRINDING & SIEVING TABLET COATING Worldwide, L.B. Bohle‘s grinding and sieving machines are recognized as the most advanced for precision particle size reduction according to industry standards. The technology-leading coaters from L.B. Bohle guarantee first-class product processing with high profitability. Perfect handling is a key factor in optimizing production processes. CONTINUOUS MANUFACTURING...

CONTAINMENT The Hot Topic in Solid Dosage Form Production In the pharmaceutical industry, one term is becoming increasingly important: containment. It describes the process of containing a substance within a defined space, a method that is suitable for protecting operators and the environment in case of high toxicity and product reactivity. At the same time, containment prevents dust, gases or vapours from being released into the environment and contaminating the product. More than 60 percent of pharmaceutical products are produced as tablets, capsules, lozenges or similar solids. Especially...

Diagram for evaluating container size (viable with patented blending baffles) Filling grade from 20-85 % MC/MT 2000 MC/MT 1800 MC/MT 1600 CONTAINERS It is important to define the design of the IBC for every single containment project early on. The IBC can be used flexible in production process and must be filled, docked, undocked, washed etc. The container needs to be connected to every individual unit operation from dispensing to packaging under high containment conditions, and therefore is subject to many interfaces. Container size Blending volume (litre) L.B. Bohle offers several containers...

Container Dimensions MCL 600 MCG 1200 Container Dimensions MT 2200 A TC 600 PEB 140 Size [L] 600 1200 Size [l] 2200 600 140 Diameter [mm] 1100 1250 Length & Width [mm] 1200 1220 540 High Containment

CASE STUDY Dry Granulation – BRC 100 Continuous dry granulation has been an established process in the pharmaceutical industry for decades and is not only used for moisture- or temperature-sensitive products. Unlike traditional wet granulation methods, this process does not require energy-intensive drying processes, eliminating the need for large investments in equipment and production facilities and lowering the cost per batch. Dry granulation is often the process of choice in particular for high-volume or moisturesensitive products. The BRC containment is proven through the typical BRC attributes....

CASE STUDY VMA Single-Pot Granulator for Global Player from Switzerland In 2020 we installed an all-in-one solution for blending, sieving, wet granulation and compressing solids at a facility in Germany. With this complex system, which was installed in one room, our customer can modernize its manufacturing process. At the same time, the system increases personal protection as well as production capacity. The key component of the project is the VMA single pot granulator in explosion-proof design including feeding. In addition, the combined mixing and sieving station, which consists of a lifting...

CASE STUDY Fully-integrated System: Container Blending, Transfer and Milling Station HIGHEST FLEXIBILITY AND SECURITY FOR YOUR PROCESS The blender has an extended hoist to enable maximum lifting capability in height. It can pick up containers as well as bins for blending and lifting. The column to the right holds a special load arm which carries a straight transfer pipe as well as a conical mill. Each in between two active sections of a split butterfly valve. This column can swivel underneath a lifted container to serve as a transfer- or milling station under contained conditions. The station...

CASE STUDYTablet Coating - Film Coater BFC100 The Bohle Film Coater BFC has been a cutting-edge technology on the market for years and have guaranteed top-quality product processing and high profitability. The BFC Film Coater and its scaled-down version, the BTC, have achieved excellent market penetration. According to customer specifications, the developers of L.B. Bohle designed a BFC 100 that meets the latest containment requirements. THE CONTAINMENT VERSION OF THE BFC 100 ENABLES OPERATION IN CLOSED DRIVING MODE THANKS TO: >/ Automatic nozzle adjustment (stroke and angle) >/ Infra-red product...

CASE STUDY Laboratory Coater – BFC 5 A multinational corporation from Great Britain has entrusted L.B. Bohle with a very special task: Construction of a containment coater for research and development. Standard BFC 5 as a base The Laboratory Coater BFC 5, which is currently used successfully in product development and for small batches, served as the basis machine for the project. In a second step, L.B. Bohle configured the BFC as a high containment coater. A challenge was the installation of the entire technology in the smaller system. The engineers at L.B. Bohle adopted some elements from projects...

L.B. Bohle Maschinen und Verfahren GmbH Industriestr. 18 D–59320 Ennigerloh +49 25 24 93 23 0 [email protected] www.lbbohl