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Labthink Instruments Co., Ltd.
Testing Oxygen and Water Vapor Barrier Properties of Aluminum-Plastic Composite Pharmaceutical Packaging

Testing Oxygen and Water Vapor Barrier Properties of Aluminum-Plastic Composite Pharmaceutical Packaging

Product catalog summary

Introduction
Pharmaceutical packaging plays a crucial role in protecting drug products from environmental factors that can affect their safety, efficacy, and quality. Aluminum-plastic composite films are commonly used for packaging moisture- and oxygen-sensitive medications due to their excellent barrier properties.

Key Properties
Two critical properties that need to be controlled in pharmaceutical packaging are oxygen and water vapor transmission. Oxygen can lead to the oxidation and degradation of active pharmaceutical ingredients, while moisture can cause chemical degradation, alter physical properties, and promote microbial growth.

Testing Methods
Several standardized methods exist for testing these barrier properties:

Oxygen Transmission Rate (OTR): Measured using coulometric or pressure difference methods. Coulometric methods (ASTM D3985, ISO 15105-2) use an oxygen sensor to measure permeation, while pressure difference methods (ASTM F1307, ISO 15105-1) measure pressure changes due to oxygen permeation.
Water Vapor Transmission Rate (WVTR): Determined using gravimetric methods (ASTM E96, ISO 2528) or the modulated infrared sensor method (ASTM F1249).

Labthink C406H Test System
The Labthink C406H system uses a coulometric oxygen sensor and an infrared water vapor sensor, designed according to ASTM and ISO standards, to provide precise and efficient testing of oxygen and water vapor transmission rates for various materials.

Importance of Regular Testing
Regular testing according to these standards is essential for ensuring the quality and safety of pharmaceutical products. By maintaining robust quality control measures, manufacturers can protect medications from degradation and maintain their therapeutic effectiveness.

Conclusion
As the demand for functional packaging grows, testing methods continue to evolve. Labthink encourages collaboration with companies for quality control to ensure comprehensive evaluation of film materials.

Catalog excerpts

Testing Oxygen and Water Vapor Barrier Properties of Aluminum-Plastic Composite Pharmaceutical Packaging-1

Labthink Instruments Co., Ltd. [email protected] +86-531-85068566 Testing Oxygen and Water Vapor Barrier Properties of Aluminum-Plastic Composite Pharmaceutical Packaging Pharmaceutical packaging protects drug products from environmental factors that can compromise their safety, efficacy, and quality. Among various packaging materials, aluminum-plastic composite films are widely used, especially for moisture- and oxygensensitive medications like powders, due to their excellent barrier properties. Therefore, rigorous testing is necessary. Oxygen and water vapor transmission are two key properties that must be controlled. Oxygen can cause oxidation of active pharmaceutical ingredients, leading to degradation and loss of potency. Moisture can similarly promote chemical degradation, alter physical properties, and encourage microbial growth. Therefore, evaluating the barrier performance of aluminum-plastic composite packaging against these elements is crucial for ensuring drug stability and extending shelf life. Several standardized test methods exist for quantifying these barrier properties. Oxygen transmission rate (OTR) is typically measured using coulometric or pressure difference methods. Coulometric methods, as described in ASTM D3985 and ISO 15105-2, involve measuring the amount of oxygen that permeates through a sample film over a specific time 1

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Testing Oxygen and Water Vapor Barrier Properties of Aluminum-Plastic Composite Pharmaceutical Packaging-2

Labthink Instruments Co., Ltd. [email protected] +86-531-85068566 period using an oxygen sensor. Pressure difference methods, such as those detailed in ASTM F1307 and ISO 15105-1, determine OTR by measuring the pressure change in a test chamber caused by oxygen permeation. Water vapor transmission rate (WVTR) is commonly determined using gravimetric methods, also known as cup methods. These methods, outlined in ASTM E96 and ISO 2528, involve sealing a desiccant inside a test cup with the packaging material as a lid and measuring the weight gain of the desiccant over time due to absorbed moisture....

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Testing Oxygen and Water Vapor Barrier Properties of Aluminum-Plastic Composite Pharmaceutical Packaging-3

Labthink Instruments Co., Ltd. [email protected] +86-531-85068566 Regular testing of oxygen and water vapor barrier properties according to these standards is essential for pharmaceutical manufacturers to ensure the quality and safety of their products throughout the supply chain and until the point of consumption. By maintaining robust quality control measures on packaging materials, manufacturers can effectively protect medications from degradation and maintain their therapeutic effectiveness. As the demand for functional packaging grows, testing methods are evolving to ensure a more comprehensive...

Open the catalog to page 3

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