► Continuous counter-current chromatography

In SMB processes you do not have to decide for either yield or purity – go for both! The high efficiency of SMB allows for > 99% yield and purity simultaneously. Continuous counter-current chromatography, also known as Simulated Moving Bed Chromatography (SMB) is a highly efficient separation technique in the field of preparative chromatography. It enables binary or pseudo binary mixtures to be separated into pure substances or fractions with maximum yield and purity. In an SMB process, a movement of the solid phase in a counter-current direction to the movement of the liquid phase is simulated....

Multi-function valve for column switching Very small hold-up volume Made of inert Hastelloy Different valve seals for a wide range of applications

What makes us attractive? It’s about the inner values. KNAUER SMB chromatography systems are very reliable due to the use of high quality components and materials. The modular design makes them adaptable to different tasks, while preseving your investment. The systems feature a very small hold-up volume for as little as possible losses of valuable product. Rack with pumps and valves They come with user-friendly control software ChromGate® SMB. All KNAUER SMB systems can be equipped with the efficiency enhancement Modicon® which can boost high SMB productivity by up to 50%. Multi function valve...

System specifications System specifications Max flow rate (ml/min) Max flow rate (ml/min) Multi-function valve Multi-function valve Available pump heads (ml/min) Available pump heads (ml/min) Pressure rating Pressure rating Number of columns with inner diameter 16 mm Total column weight max. Number of columns with inner diameter 30 mm Pump Type Total column weight max. Flow meter for flow rate monitoring Pump Type Tubing, fittings and accessories 1/8“ stainless steel (PEEK upon request) Flow meter for flow monitoring Application Area Kilogram-scale production Tubing, fittings and accessories...

System control We also offer non-standard systems on request. We design a tailor-made system according to your preference and purification task. The KNAUER SMB systems can be controlled by ChromGate® SMB, which is based on the well-known EZChrom Elite kernel. Usage is as easy as with analytical and preparative HPLC systems. The integration into KNAUER’s ChromGate chromatography data system gives access to drivers for a wide range of additional instruments for individual setups. SMB System CSEP® C9116 Pilot Unit The system is designed for the extraction of pure substances in the gram-scale. Tubing...

Separation impossible? Strongly overlapping components, which can hardly be purified using preparative batch HPLC, pose no separation problem to SMB. This is made possible through the internal recycling nature of the process, which virtually extends the column length as required and keeps losses to a minimum. How important are time, space, and operating costs for you? Work faster Due to the continuous “injection“ (feed) and separation in SMB there are no such things as “runs“ or “latency between runs“. In SMB “operation time“ equals “separation time“. The result is much higher productivity than...

Why Knauer SMB? KNAUER SMB systems are characterized by their modular setup. This makes them flexible and allows for individual configurations. Central element of the KNAUER CSEP® SMB system is the multifunction valve made of Hastelloy which connects the inlets and outlets of the columns with the pumps. Since only one valve is required for column switching, the KNAUER SMB system is particularly compact and uncluttered. Flexible KNAUER SMB comes on a trolley rack and requires only standard power supply. The system dead volume is significantly lower than that of systems with several valves. In...

Looking for professionals? KNAUER columns and method development service With our experience in manufacturing analytical and preparative HPLC columns, we can supply sets of columns with outstanding similarity in a wide range of stationary phases. KNAUER’s high pressure glass columns with adjustable bed length provide the user with the opportunity to change the resin quickly and are also ideal for separating biomolecules. Our application lab offers the screening of stationary phases as well as detailed method development studies. These services reduce your effort in method development and ensure...